TY - JOUR
T1 - Advanced Imaging and Technology in Gastrointestinal Neoplasia
T2 - Summary of the AGA-NCI Symposium October 4-5, 2004
AU - Wallace, Michael B.
AU - Sullivan, Daniel
AU - Rustgi, Anil K.
N1 - Funding Information:
This symposium, jointly sponsored by the American Gastroenterological Association and the National Cancer Institute, has focused our attention on the tremendous potential for new imaging technologies to advance our understanding of, and hopefully our ability to care for, patients with gastrointestinal neoplasia. It has identified several key priorities for research and funding as highlighted in each section earlier. It is clear that advances in imaging of gastrointestinal disease, particularly neoplasia, are progressing at an increasingly rapid rate. These advances are now entering the clinical arena with several major endoscopic manufacturers developing clinically relevant endoscopic technologies. AITGN Symposium Faculty and Topics: The Molecular Pathology of GI Neoplasia: Raymond DuBois, MD, PhD (The Vanderbilt-Ingram Cancer Center, Nashville, TN); Endoluminal Imaging: State of the Art and Challenges: Michael B. Wallace, MD (Mayo Clinic, Jacksonville, FL), and Kenneth Wang, MD (Mayo Clinic, Rochester, MN); Molecular and Cellular Imaging: Ralph Weissleder, MD, PhD (Harvard University, Boston, MA); Biomedical Imaging Technology: Pablo R. Ros, MD, MPH (Brigham & Women’s Hospital, Boston, MA), and Sukru Mehmet Erturk, MD (Brigham & Women’s Hospital, Boston, MA); Molecular Pathology and Biomarkers in Barrett’s Esophagus: Peter S. Rabinovitch, MD, PhD (University of Washington, Seattle, WA), Patricia L. Blount, MD (University of Washington, Seattle, WA), and Brian J. Reid, MD, PhD (University of Washington, Seattle WA); Enhanced Magnification Endoscopy in Barrett’s Esophagus: Moises Guelrud, MD (New England Medical Center, Boston, MA); Role of Narrow Band Imaging in Barrett’s Esophagus: Prateek Sharma, MD (VA Medical Center, Kansas City, MO); Spectroscopy, Fluorescence Imaging, and Reflectance Imaging: James Tunnell, PhD (Massachusetts Institute of Technology, Cambridge, MA), and Michael S. Feld, PhD (Massachusetts Institute of Technology, Cambridge, MA); Endoscopic Ultrasound Imaging of Gastrointestinal Neoplasia: Michael L. Kochman, MD, FACP (Hospital of University of Pennsylvania, Philadelphia, PA); Gastrointestinal Optical Coherence Tomography: Clinical Applications and Limitations: Gerard Isenberg, MD (Case Western, Cleveland, OH); State-of-the-Art of OCT Technology for GI Cancer Imaging: Joseph Schmitt, PhD (Lightlab Imaging, Westford, MA), and Thomas Wang, MD, PhD (Stanford University, Stanford, CA); CT Colonography (Virtual Colonoscopy): Douglas K. Rex, MD (Indiana University Medical Center, Indianapolis, IN); Virtual Colonoscopy (VC): Comments on Clinical Results and Research Opportunities: Joseph T. Ferrucci, MD (Boston University Medical Center, Boston, MA); Wireless Capsule Endoscopy: Paul Swain, MD (Royal London Hospital, London, England); Molecular Probes for Endoscopic Imaging: Umar Mahmood, MD, PhD (Massachusetts General Hospital, Charlestown, MA); Delivering Probes Into Cells: Molecular Imaging of Reporter Genes and Endogenous Genes: Anna M. Wu, PhD (UCLA School of Medicine, Los Angeles, CA); Potential Applications of Nanoshells in Imaging Neoplasia: Rebekah Drezek, PhD (Rice University, Houston, TX), Jennifer West (Rice University, Houston, TX), and Naomi Halas (Rice University, Houston, TX); Nanotechnology: New Methods for Understanding Cell Signaling: Frederick R. Maxfield, PhD (Cornell University, New York, NY); Imaging Mechanisms of Resistance to Cancer Therapy: Kenneth A. Krohn, PhD (University of Washington, Seattle, WA); Aberrant Crypt Foci: Biology of ACFs: Nicole Murray, Ph.D. (Mayo Clinic Foundation, Jacksonville, FL); and Spectroscopic Imaging of Colon Dysplasia: James Tunnell, MD (Massachusetts Institute of Technology, Cambridge, MA), and Michael S. Feld, PhD (Massachusetts Institute of Technology, Cambridge, MA).
PY - 2006/4
Y1 - 2006/4
N2 - Imaging and other advanced technologies for detection of gastrointestinal cancers are undergoing a major revolution on several fronts. This is facilitated by convergence of key technologies including advanced endoscopic-detection systems, more specific contrast agents, rapid and high-resolution cross-sectional imaging, and miniaturization of construction systems for making all imaging equipment smaller and less invasive. This convergence is occurring along traditional translational research pathways (clinical medicine-molecular biology) as well as nontraditional lines (clinical medicine-optical physics/engineering and molecular biology-optical physics/engineering). These new efforts are producing a wide array of technologies aimed at improving detection, classification, and monitoring of gastrointestinal neoplasia, especially for colorectal and esophageal cancer because of easier accessibility. A critical goal is to detect lesions at their premalignant stages, thereby permitting meaningful intervention. Inspired by these advances, the American Gastroenterological Association and the National Cancer Institute sponsored a symposium held in Bethesda, MD, from October 4-5, 2004, bringing together leading investigators with diverse backgrounds in imaging technology. The aims of this symposium were to summarize the state of the art and priorities for research in the coming decade in the field of imaging and advanced technology for gastrointestinal neoplasia. In this overview, we summarize the salient results of that symposium. The initial sections discuss the major technologies in each area of endoluminal imaging and molecular imaging followed by applications to specific diseases such as Barrett's esophagus and colon neoplasia. Each section focuses on the current state of the art then lists major priorities for research in the field.
AB - Imaging and other advanced technologies for detection of gastrointestinal cancers are undergoing a major revolution on several fronts. This is facilitated by convergence of key technologies including advanced endoscopic-detection systems, more specific contrast agents, rapid and high-resolution cross-sectional imaging, and miniaturization of construction systems for making all imaging equipment smaller and less invasive. This convergence is occurring along traditional translational research pathways (clinical medicine-molecular biology) as well as nontraditional lines (clinical medicine-optical physics/engineering and molecular biology-optical physics/engineering). These new efforts are producing a wide array of technologies aimed at improving detection, classification, and monitoring of gastrointestinal neoplasia, especially for colorectal and esophageal cancer because of easier accessibility. A critical goal is to detect lesions at their premalignant stages, thereby permitting meaningful intervention. Inspired by these advances, the American Gastroenterological Association and the National Cancer Institute sponsored a symposium held in Bethesda, MD, from October 4-5, 2004, bringing together leading investigators with diverse backgrounds in imaging technology. The aims of this symposium were to summarize the state of the art and priorities for research in the coming decade in the field of imaging and advanced technology for gastrointestinal neoplasia. In this overview, we summarize the salient results of that symposium. The initial sections discuss the major technologies in each area of endoluminal imaging and molecular imaging followed by applications to specific diseases such as Barrett's esophagus and colon neoplasia. Each section focuses on the current state of the art then lists major priorities for research in the field.
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U2 - 10.1053/j.gastro.2006.01.009
DO - 10.1053/j.gastro.2006.01.009
M3 - Article
C2 - 16618424
AN - SCOPUS:33646015376
SN - 0016-5085
VL - 130
SP - 1333
EP - 1342
JO - Gastroenterology
JF - Gastroenterology
IS - 4
ER -