Adiponectin and catecholamine concentrations during acute exercise in children with type 1 diabetes

Nelly Mauras, Kraig Kollman, Michael W. Steffes, Ravinder Singh, Rosanna Fiallo-Scharer, Eva Tsalikian, Stuart A. Weinzimer, Bruce Buckingham, Roy W. Beck, Katrina J. Ruedy, Dongyuan Xing, William V. Tamborlane

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Objective: Adiponectin, an adipokine secreted by the adipocyte, is inversely related to adiposity and directly related to insulin sensitivity. In type 1 diabetes mellitus (T1DM), however, data thus far are contradictory. We investigated the relationship between adiponectin and exercise inT1DM. Methods: Forty-nine children (14.5 ± 2.0 yr, range 8-17 yr) with T1DM on an insulin pump were studied during two 75-min exercise sessions with and without continuation of the basal rate within 4 wk. Adiponectin and epinephrine concentrations were measured before and during exercise. Results: Mean preexercise adiponectin concentration was 11.2 ± 4.7 mg/L (range 2.7-23.0 mg/L) with a mean absolute difference of 1.7 mg/L between the 2d. Adiponectin concentrations did not change meaningfully during exercise (mean change: -0.1±1.2mg/L; p = 0.17). Adiponectin correlated inversely with body mass index percentile (p = 0.02) but not with age, gender, duration of diabetes, hemoglobin A1c, or preexercise glucose. However, those with higher baseline adiponectin concentrations were less likely to become hypoglycemic during exercise, 36% becoming hypoglycemic when baseline adiponectin concentration was <10mg/L, 42% when 10 to <15 mg/L, and 15% when ≥15 mg/L (p = 0.02). Baseline epinephrine concentrations were not associated with adiponectin, and in those whose nadir glucose was ≤100 mg/dL, there was no correlation between epinephrine response and adiponectin (p = 0.16). Conclusions: Adiponectin concentrations are stable from day to day, are not affected by acute exercise or metabolic control, and vary inversely with adiposity. Higher adiponectin concentration appears to be associated with a decrease in hypoglycemia risk during exercise. Further studies are needed to examine whether adiponectin protects against exercise-induced hypoglycemia by directly enhancing the oxidation of alternate fuels.

Original languageEnglish (US)
Pages (from-to)221-227
Number of pages7
JournalPediatric Diabetes
Issue number3 PART 1
StatePublished - Jun 2008


  • Adiponectin
  • Exercise
  • Hypoglycemia
  • Insulin pump
  • T1DM

ASJC Scopus subject areas

  • Internal Medicine
  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism


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