ADAM-17: A target to increase chemotherapeutic efficacy in colorectal cancer?

Adam M. Lee; Robert B. Diasio

doi:10.1158/1078-0432.CCR-10-1059

ADAM-17: A target to increase chemotherapeutic efficacy in colorectal cancer?

Adam M. Lee
, Robert B. Diasio

Pharmacology

Research output: Contribution to journal › Comment/debate › peer-review

3 Scopus citations

Abstract

Chemotherapy-induced activation of ADAM-17 results in increased growth factor shedding and activation of growth factor receptor-mediated pro-survival response. Enhanced ADAM-17 activity and HER ligand shedding results in resistance to chemotherapy in CRC. Therapies that decrease ADAM-17 activity in conjunction with current treatments may enhance response rates in advanced CRC patients.

Original language	English (US)
Pages (from-to)	3319-3321
Number of pages	3
Journal	Clinical Cancer Research
Volume	16
Issue number	13
DOIs	https://doi.org/10.1158/1078-0432.CCR-10-1059
State	Published - Jul 1 2010

ASJC Scopus subject areas

General Medicine

Access to Document

10.1158/1078-0432.CCR-10-1059

Cite this

@article{b89c842ce1f34d02bcbbf382649e7148,

title = "ADAM-17: A target to increase chemotherapeutic efficacy in colorectal cancer?",

abstract = "Chemotherapy-induced activation of ADAM-17 results in increased growth factor shedding and activation of growth factor receptor-mediated pro-survival response. Enhanced ADAM-17 activity and HER ligand shedding results in resistance to chemotherapy in CRC. Therapies that decrease ADAM-17 activity in conjunction with current treatments may enhance response rates in advanced CRC patients.",

author = "Lee, \{Adam M.\} and Diasio, \{Robert B.\}",

year = "2010",

month = jul,

day = "1",

doi = "10.1158/1078-0432.CCR-10-1059",

language = "English (US)",

volume = "16",

pages = "3319--3321",

journal = "Clinical Cancer Research",

issn = "1078-0432",

publisher = "American Association for Cancer Research Inc.",

number = "13",

}

TY - JOUR

T1 - ADAM-17

T2 - A target to increase chemotherapeutic efficacy in colorectal cancer?

AU - Lee, Adam M.

AU - Diasio, Robert B.

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Chemotherapy-induced activation of ADAM-17 results in increased growth factor shedding and activation of growth factor receptor-mediated pro-survival response. Enhanced ADAM-17 activity and HER ligand shedding results in resistance to chemotherapy in CRC. Therapies that decrease ADAM-17 activity in conjunction with current treatments may enhance response rates in advanced CRC patients.

AB - Chemotherapy-induced activation of ADAM-17 results in increased growth factor shedding and activation of growth factor receptor-mediated pro-survival response. Enhanced ADAM-17 activity and HER ligand shedding results in resistance to chemotherapy in CRC. Therapies that decrease ADAM-17 activity in conjunction with current treatments may enhance response rates in advanced CRC patients.

UR - https://www.scopus.com/pages/publications/77954232250

UR - https://www.scopus.com/pages/publications/77954232250#tab=citedBy

U2 - 10.1158/1078-0432.CCR-10-1059

DO - 10.1158/1078-0432.CCR-10-1059

M3 - Comment/debate

C2 - 20570925

AN - SCOPUS:77954232250

SN - 1078-0432

VL - 16

SP - 3319

EP - 3321

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 13

ER -

ADAM-17: A target to increase chemotherapeutic efficacy in colorectal cancer?

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this