TY - JOUR
T1 - Acute Topiramate Toxicity
AU - Traub, Stephen J.
AU - Howland, Mary Ann
AU - Hoffman, Robert S.
AU - Nelson, Lewis S.
PY - 2003/12/1
Y1 - 2003/12/1
N2 - Topiramate (Topamax®) is an anti-epileptic medication for which acute toxicity is infrequently reported. A 5-yr-old girl, not previously taking topiramate, developed neurological symptoms after acute ingestion of this medication. She was intermittently agitated, complained of "not being able to feel anything," demonstrated arching movements of the back, and perseverated upon questioning. Computerized tomography of the head and electroencephalography were both normal, and urine toxicology testing for drugs of abuse was negative. A serum topiramate level was 10.5 mcg/mL, confirming the ingestion. The patient was observed for 24 h, over which time her symptoms completely resolved.
AB - Topiramate (Topamax®) is an anti-epileptic medication for which acute toxicity is infrequently reported. A 5-yr-old girl, not previously taking topiramate, developed neurological symptoms after acute ingestion of this medication. She was intermittently agitated, complained of "not being able to feel anything," demonstrated arching movements of the back, and perseverated upon questioning. Computerized tomography of the head and electroencephalography were both normal, and urine toxicology testing for drugs of abuse was negative. A serum topiramate level was 10.5 mcg/mL, confirming the ingestion. The patient was observed for 24 h, over which time her symptoms completely resolved.
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U2 - 10.1081/CLT-120026522
DO - 10.1081/CLT-120026522
M3 - Article
C2 - 14705846
AN - SCOPUS:0346734260
SN - 0731-3810
VL - 41
SP - 987
EP - 990
JO - Journal of Toxicology - Clinical Toxicology
JF - Journal of Toxicology - Clinical Toxicology
IS - 7
ER -