Acupuncture modulates expressions of nitric oxide synthase and c-Fos in hippocampus after transient global ischemia in gerbils

Ji Eun Kang; Hye Jung Lee; Sabina Lim; Ee Hwa Kim; Tae Hee Lee; Mi Hyeon Jang; Min Chul Shin; Baek Vin Lim; Youn Jung Kim; Chang Ju Kim

doi:10.1142/S0192415X03001235

Acupuncture modulates expressions of nitric oxide synthase and c-Fos in hippocampus after transient global ischemia in gerbils

Ji Eun Kang, Hye Jung Lee, Sabina Lim, Ee Hwa Kim, Tae Hee Lee, Mi Hyeon Jang, Min Chul Shin, Baek Vin Lim, Youn Jung Kim, Chang Ju Kim

Neurosurgery

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of acupuncture on the expressions of nitric oxide synthase (NOS) and c-Fos in the hippocampus of gerbils after transient ischemia were investigated via nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry and Fos immunohistochemistry. In animals of the ischemia-induction groups, both common carotid arteries were occluded for 5 minutes. Animals of the acupunctued groups were given acupunctural treatment at Zusanli twice daily for 9 consecutive days. Acupuncture was shown to decrease NADPH-d and c-Fos levels in both the sham-operation group and the ischemia-induction group. These results suggest that acupuncture modulates the expressions of NOS and c-Fos in the hippocampus.

Original language	English (US)
Pages (from-to)	581-590
Number of pages	10
Journal	American Journal of Chinese Medicine
Volume	31
Issue number	4
DOIs	https://doi.org/10.1142/S0192415X03001235
State	Published - 2003

Keywords

Acupuncture
Hippocampus
Nitric Oxide Synthase
Zusanli Acupoint
c-Fos

ASJC Scopus subject areas

Complementary and alternative medicine

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10.1142/S0192415X03001235

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@article{60453e63f4fe43a7920c9cf8b5b8b776,

title = "Acupuncture modulates expressions of nitric oxide synthase and c-Fos in hippocampus after transient global ischemia in gerbils",

abstract = "The effects of acupuncture on the expressions of nitric oxide synthase (NOS) and c-Fos in the hippocampus of gerbils after transient ischemia were investigated via nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry and Fos immunohistochemistry. In animals of the ischemia-induction groups, both common carotid arteries were occluded for 5 minutes. Animals of the acupunctued groups were given acupunctural treatment at Zusanli twice daily for 9 consecutive days. Acupuncture was shown to decrease NADPH-d and c-Fos levels in both the sham-operation group and the ischemia-induction group. These results suggest that acupuncture modulates the expressions of NOS and c-Fos in the hippocampus.",

keywords = "Acupuncture, Hippocampus, Nitric Oxide Synthase, Zusanli Acupoint, c-Fos",

author = "Kang, {Ji Eun} and Lee, {Hye Jung} and Sabina Lim and Kim, {Ee Hwa} and Lee, {Tae Hee} and Jang, {Mi Hyeon} and Shin, {Min Chul} and Lim, {Baek Vin} and Kim, {Youn Jung} and Kim, {Chang Ju}",

note = "Funding Information: This study was supported by a grant of the Oriental Medicine R&D Project, Ministry of Health and Welfare, Republic of Korea (HMP-02-PJ9-PG3-20600-0007).",

year = "2003",

doi = "10.1142/S0192415X03001235",

language = "English (US)",

volume = "31",

pages = "581--590",

journal = "American Journal of Chinese Medicine",

issn = "0192-415X",

publisher = "World Scientific Publishing Co. Pte Ltd",

number = "4",

}

TY - JOUR

T1 - Acupuncture modulates expressions of nitric oxide synthase and c-Fos in hippocampus after transient global ischemia in gerbils

AU - Kang, Ji Eun

AU - Lee, Hye Jung

AU - Lim, Sabina

AU - Kim, Ee Hwa

AU - Lee, Tae Hee

AU - Jang, Mi Hyeon

AU - Shin, Min Chul

AU - Lim, Baek Vin

AU - Kim, Youn Jung

AU - Kim, Chang Ju

N1 - Funding Information: This study was supported by a grant of the Oriental Medicine R&D Project, Ministry of Health and Welfare, Republic of Korea (HMP-02-PJ9-PG3-20600-0007).

PY - 2003

Y1 - 2003

N2 - The effects of acupuncture on the expressions of nitric oxide synthase (NOS) and c-Fos in the hippocampus of gerbils after transient ischemia were investigated via nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry and Fos immunohistochemistry. In animals of the ischemia-induction groups, both common carotid arteries were occluded for 5 minutes. Animals of the acupunctued groups were given acupunctural treatment at Zusanli twice daily for 9 consecutive days. Acupuncture was shown to decrease NADPH-d and c-Fos levels in both the sham-operation group and the ischemia-induction group. These results suggest that acupuncture modulates the expressions of NOS and c-Fos in the hippocampus.

AB - The effects of acupuncture on the expressions of nitric oxide synthase (NOS) and c-Fos in the hippocampus of gerbils after transient ischemia were investigated via nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry and Fos immunohistochemistry. In animals of the ischemia-induction groups, both common carotid arteries were occluded for 5 minutes. Animals of the acupunctued groups were given acupunctural treatment at Zusanli twice daily for 9 consecutive days. Acupuncture was shown to decrease NADPH-d and c-Fos levels in both the sham-operation group and the ischemia-induction group. These results suggest that acupuncture modulates the expressions of NOS and c-Fos in the hippocampus.

KW - Acupuncture

KW - Hippocampus

KW - Nitric Oxide Synthase

KW - Zusanli Acupoint

KW - c-Fos

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DO - 10.1142/S0192415X03001235

M3 - Article

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AN - SCOPUS:1542463944

SN - 0192-415X

VL - 31

SP - 581

EP - 590

JO - American Journal of Chinese Medicine

JF - American Journal of Chinese Medicine

IS - 4

ER -

Acupuncture modulates expressions of nitric oxide synthase and c-Fos in hippocampus after transient global ischemia in gerbils

Abstract

Keywords

ASJC Scopus subject areas

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