Acupuncture decreases nitric oxide synthase expression in periaqueductal gray area of rats with streptozotocin-induced diabetes

Mi Hyeon Jang; Min Chul Shin; Gyo Sung Koo; Choong Yeol Lee; Ee Hwa Kim; Chang Ju Kim

doi:10.1016/S0304-3940(02)01318-6

Acupuncture decreases nitric oxide synthase expression in periaqueductal gray area of rats with streptozotocin-induced diabetes

Mi Hyeon Jang, Min Chul Shin, Gyo Sung Koo, Choong Yeol Lee, Ee Hwa Kim, Chang Ju Kim

Neurosurgery

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Acupuncture has been used as a clinical treatment in Oriental medicine for various diseases including diabetes mellitus, one of the most common metabolic disorders in humans. In the present study, the effect of acupuncture on the expressions of neuronal nitric oxide synthase (nNOS) and nitric oxide synthase (NOS) in the dorsolateral periaqueductal gray (DL-PAG) area of rats with streptozotocin (STZ)-induced diabetes was investigated via nNOS immunohistochemistry and nicotinamide adenine dinucleotide phosphate-diaphorase histochemistry. Enhanced expression of nNOS and NOS was detected in the DL-PAG of rats with STZ-induced diabetes, and acupunctural treatment at Zusanli acupoint suppressed the diabetes-induced enhancement in the expression of nNOS and NOS. The present results demonstrate that acupuncture is effective in the modulation of the expression of nNOS and NOS in the DL-PAG under diabetic conditions.

Original language	English (US)
Pages (from-to)	155-158
Number of pages	4
Journal	Neuroscience Letters
Volume	337
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(02)01318-6
State	Published - Feb 13 2003

Keywords

Acupuncture
Diabetes
Dorsolateral periaqueductal gray
Neuronal nitric oxide synthase
Nitric oxide synthase

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(02)01318-6

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title = "Acupuncture decreases nitric oxide synthase expression in periaqueductal gray area of rats with streptozotocin-induced diabetes",

abstract = "Acupuncture has been used as a clinical treatment in Oriental medicine for various diseases including diabetes mellitus, one of the most common metabolic disorders in humans. In the present study, the effect of acupuncture on the expressions of neuronal nitric oxide synthase (nNOS) and nitric oxide synthase (NOS) in the dorsolateral periaqueductal gray (DL-PAG) area of rats with streptozotocin (STZ)-induced diabetes was investigated via nNOS immunohistochemistry and nicotinamide adenine dinucleotide phosphate-diaphorase histochemistry. Enhanced expression of nNOS and NOS was detected in the DL-PAG of rats with STZ-induced diabetes, and acupunctural treatment at Zusanli acupoint suppressed the diabetes-induced enhancement in the expression of nNOS and NOS. The present results demonstrate that acupuncture is effective in the modulation of the expression of nNOS and NOS in the DL-PAG under diabetic conditions.",

keywords = "Acupuncture, Diabetes, Dorsolateral periaqueductal gray, Neuronal nitric oxide synthase, Nitric oxide synthase",

author = "Jang, {Mi Hyeon} and Shin, {Min Chul} and Koo, {Gyo Sung} and Lee, {Choong Yeol} and Kim, {Ee Hwa} and Kim, {Chang Ju}",

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AU - Jang, Mi Hyeon

AU - Shin, Min Chul

AU - Koo, Gyo Sung

AU - Lee, Choong Yeol

AU - Kim, Ee Hwa

AU - Kim, Chang Ju

PY - 2003/2/13

Y1 - 2003/2/13

N2 - Acupuncture has been used as a clinical treatment in Oriental medicine for various diseases including diabetes mellitus, one of the most common metabolic disorders in humans. In the present study, the effect of acupuncture on the expressions of neuronal nitric oxide synthase (nNOS) and nitric oxide synthase (NOS) in the dorsolateral periaqueductal gray (DL-PAG) area of rats with streptozotocin (STZ)-induced diabetes was investigated via nNOS immunohistochemistry and nicotinamide adenine dinucleotide phosphate-diaphorase histochemistry. Enhanced expression of nNOS and NOS was detected in the DL-PAG of rats with STZ-induced diabetes, and acupunctural treatment at Zusanli acupoint suppressed the diabetes-induced enhancement in the expression of nNOS and NOS. The present results demonstrate that acupuncture is effective in the modulation of the expression of nNOS and NOS in the DL-PAG under diabetic conditions.

AB - Acupuncture has been used as a clinical treatment in Oriental medicine for various diseases including diabetes mellitus, one of the most common metabolic disorders in humans. In the present study, the effect of acupuncture on the expressions of neuronal nitric oxide synthase (nNOS) and nitric oxide synthase (NOS) in the dorsolateral periaqueductal gray (DL-PAG) area of rats with streptozotocin (STZ)-induced diabetes was investigated via nNOS immunohistochemistry and nicotinamide adenine dinucleotide phosphate-diaphorase histochemistry. Enhanced expression of nNOS and NOS was detected in the DL-PAG of rats with STZ-induced diabetes, and acupunctural treatment at Zusanli acupoint suppressed the diabetes-induced enhancement in the expression of nNOS and NOS. The present results demonstrate that acupuncture is effective in the modulation of the expression of nNOS and NOS in the DL-PAG under diabetic conditions.

KW - Acupuncture

KW - Diabetes

KW - Dorsolateral periaqueductal gray

KW - Neuronal nitric oxide synthase

KW - Nitric oxide synthase

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Acupuncture decreases nitric oxide synthase expression in periaqueductal gray area of rats with streptozotocin-induced diabetes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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