Acupuncture decreases ischemia-induced apoptosis and cell proliferation in dentate gyrus of gerbils

Jae Hoon Chung, Eun Yong Lee, Mi Hyeon Jang, Chang Ju Kim, Jeongseon Kim, Eunyoung Ha, Hun Kuk Park, Sun Mi Choi, Hyejung Lee, Sung Ho Park, Kang Hyun Leem, Ee Hwa Kim

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Background: Acupuncture has been used for the enhancement of functional recovery from various disorders. In the present study, the effect of acupuncture on the apoptosis and new cell proliferation in the hippocampal dentate gyrus of gerbils (n=25) following transient global ischemia was investigated. Methods: To determine the level of apoptosis and cell proliferation, terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay and immunohistochemistry for 5-bromo-2′-deoxyuridine (BrdU) were employed respectively. Results: In the dentate gyrus of ischemic gerbils, the number of both TUNEL- and BrdU-positive cells (66.01 ± 2.45/mm2 and 514.38 ± 44.90/mm2) was significantly increased compared to that of the sham-operated gerbils (11.25 ± 1.85/mm2 and 111.47 ± 10.95/mm2). Among the acupuncture (ST36, LI4 or non-acupoint) treated groups, ST36 acupoint treated group showed the most potent apoptosis (20.52 ± 2.40/mm2) and proliferation (159.38 ± 24.05/mm2) suppresslve effects (∼70% decreases in both apoptosis and cell proliferation). Conclusion: These results may suggest that acupuncture treatment alleviates ischemia-induced apoptosis and presents possible therapeutic potentials in the recovery from ischemic cerebral injury.

Original languageEnglish (US)
Pages (from-to)S23-S27
JournalNeurological research
Issue numberSUPPL. 1
StatePublished - 2007


  • Acupuncture
  • Apoptosis
  • Cell proliferation
  • Gerbil
  • Hippocampus
  • Ischemia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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