Acquired (Non-Wilsonian) hepatocerebral degeneration: Complex management decisions

Eelco F.M. Wijdicks, Russell H. Wiesner

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Portal systemic encephalopathy, in its many guises, can be reversible after medical management or liver transplantation. It is much less certain whether patients with a long-standing neurodegenerative syndrome (known in the medical vernacular as acquired hepatocerebral degeneration) can improve. Impressive neuroimaging abnormalities have been reported in this entity. However, the combination of a severe disabling neurologic deficit and widespread magnetic resonance abnormalities tempers the enthusiasm of transplant surgeons to proceed with liver transplantation. In our liver transplantation program, we were recently confronted with such a case, and present herein not only the characteristic magnetic resonance imaging findings but also some of the dilemmas of management.

Original languageEnglish (US)
Pages (from-to)993-994
Number of pages2
JournalLiver Transplantation
Issue number9
StatePublished - Sep 1 2003

ASJC Scopus subject areas

  • Surgery
  • Hepatology
  • Transplantation


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