Acoustically active injection catheter guided by ultrasound: Navigation tests in acutely ischemic porcine hearts

Marek Belohlavek, Minako Katayama, David Zarbatany, F. David Fortuin, Mostafa Fatemi, Ivan Z. Nenadic, Eileen M. McMahon

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Catheters are increasingly used therapeutically and investigatively. With complex usage comes a need for more accurate intracardiac localization than traditional guidance can provide. An injection catheter navigated by ultrasound was designed and then tested in an open-chest model of acute ischemia in eight pigs. The catheter is made "acoustically active" by a piezo-electric crystal near its tip, electronically controlled, vibrating in the audio frequency range and uniquely identifiable using pulsed-wave Doppler. Another "target" crystal was sutured to the epicardium within the ischemic region. Sonomicrometry was used to measure distances between the two crystals and then compared with measurements from 2-D echocardiographic images. Complete data were obtained from seven pigs, and the correlation between sonomicrometry and ultrasound measurements was excellent (p < 0.0001, ρ= 0.9820), as was the intraclass correlation coefficient (0.96) between two observers. These initial experimental results suggest high accuracy of ultrasound navigation of the acoustically active catheter prototype located inside the beating left ventricle.

Original languageEnglish (US)
Pages (from-to)1650-1659
Number of pages10
JournalUltrasound in Medicine and Biology
Issue number7
StatePublished - Jul 2014


  • Acoustic catheter
  • Pulsed-wave Doppler
  • Ultrasound navigation

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics


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