Absent prolactin response to l-tryptophan in normal and acromegalic subjects

Allan R. Glass, Robert C. Smallridge, Marcus Schaaf, Richard C. Dimond

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


l-tryptophan (5 g orally), the precursor of serotonin, was administered to 10 patients with acromegaly and eight control subjects. In normal subjects, there was no significant change in serum prolactin after l-tryptophan. In subjects with acromegaly, there was no significant net change in serum prolactin after l-tryptophan relative either to the baseline value before l-tryptophan or to values obtained on a control day without l-tryptophan. Activation of serotoninergic pathways by oral administration of the serotonin precursor l-tryptophan has no effect on serum prolactin in normal or acromegalic subjects.

Original languageEnglish (US)
Pages (from-to)261-265
Number of pages5
Issue number3
StatePublished - 1980


  • acromegaly
  • l-tryptophan
  • prolactin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Psychiatry and Mental health
  • Biological Psychiatry


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