Aberrant corneal nerve regeneration after PRK

Jay C. Erie, Sanjay V. Patel, William M. Bourne

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Purpose: To report a case of aberrant corneal nerve regeneration after myopic photorefractive keratectomy (PRK). Methods: One patient underwent bilateral PRK to correct a refractive error of -5.50 D in each eye. Thirteen months after the original PRK, the left eye underwent an uncomplicated PRK reoperation to correct a regression of -1.00 D. The central corneas were examined by confocal microscopy preoperatively in both eyes, at 1 and 2 years after the original PRK in the right eye, and before and 1 and 2 years after the PRK reoperation in the left eye. Results: Aberrant anterior stromal nerves with a coiled course and irregular branching pattern were identified 22 μm deep to the most anterior keratocyte layer at 1 year after the PRK reoperation in the left eye and remained unchanged 2 years after reoperation. No abnormal stromal nerves were identified in the left eye before the reoperation or at any time in the right eye. Conclusion: Aberrant regeneration of corneal stromal nerves may occur after myopic PRK reoperation.

Original languageEnglish (US)
Pages (from-to)684-686
Number of pages3
Issue number7
StatePublished - Oct 2003


  • Aberrant regeneration
  • Confocal microscopy
  • Corneal nerves
  • PRK

ASJC Scopus subject areas

  • Ophthalmology


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