A tearfully painful darkness

Lakshmi Leishangthem, Shannon Beres, Heather E. Moss, John Chen

Research output: Contribution to journalArticlepeer-review


A 70-year-old woman presented with new onset of left eye and facial pain. Ophthalmic and neurological examinations, magnetic resonance imaging brain, erythrocyte sedimentation rate, and C-reactive protein were unrevealing. A few days later, she developed vision loss in her left eye. Examination revealed decreased visual acuity with a relative afferent pupillary defect in the left eye and a diffuse mild swelling of the left optic nerve head. Repeat magnetic resonance imaging showed T2 hyperintensity and enhancement of the intraorbital optic nerve and surrounding tissues with no other intracranial abnormalities. Serum studies showed elevated myelin oligodendrocyte glycoprotein IgG titer. She was treated with IV methylprednisolone 1000 mg daily for 3 days and was discharged on prolonged prednisone taper with return of vision to baseline.

Original languageEnglish (US)
Pages (from-to)543-549
Number of pages7
JournalSurvey of ophthalmology
Issue number3
StatePublished - May 1 2021


  • MOG IgG
  • headache
  • myelin oligodendrocyte glycoprotein
  • optic neuritis
  • trigeminal pain

ASJC Scopus subject areas

  • Ophthalmology


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