A tearfully painful darkness

Lakshmi Leishangthem; Shannon Beres; Heather E. Moss; John Chen

doi:10.1016/j.survophthal.2020.06.002

A tearfully painful darkness

Lakshmi Leishangthem, Shannon Beres, Heather E. Moss, John Chen

Ophthalmology

Research output: Contribution to journal › Article › peer-review

Abstract

A 70-year-old woman presented with new onset of left eye and facial pain. Ophthalmic and neurological examinations, magnetic resonance imaging brain, erythrocyte sedimentation rate, and C-reactive protein were unrevealing. A few days later, she developed vision loss in her left eye. Examination revealed decreased visual acuity with a relative afferent pupillary defect in the left eye and a diffuse mild swelling of the left optic nerve head. Repeat magnetic resonance imaging showed T2 hyperintensity and enhancement of the intraorbital optic nerve and surrounding tissues with no other intracranial abnormalities. Serum studies showed elevated myelin oligodendrocyte glycoprotein IgG titer. She was treated with IV methylprednisolone 1000 mg daily for 3 days and was discharged on prolonged prednisone taper with return of vision to baseline.

Original language	English (US)
Pages (from-to)	543-549
Number of pages	7
Journal	Survey of ophthalmology
Volume	66
Issue number	3
DOIs	https://doi.org/10.1016/j.survophthal.2020.06.002
State	Published - May 1 2021

Keywords

MOG IgG
headache
myelin oligodendrocyte glycoprotein
optic neuritis
trigeminal pain

ASJC Scopus subject areas

Ophthalmology

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10.1016/j.survophthal.2020.06.002

Cite this

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title = "A tearfully painful darkness",

abstract = "A 70-year-old woman presented with new onset of left eye and facial pain. Ophthalmic and neurological examinations, magnetic resonance imaging brain, erythrocyte sedimentation rate, and C-reactive protein were unrevealing. A few days later, she developed vision loss in her left eye. Examination revealed decreased visual acuity with a relative afferent pupillary defect in the left eye and a diffuse mild swelling of the left optic nerve head. Repeat magnetic resonance imaging showed T2 hyperintensity and enhancement of the intraorbital optic nerve and surrounding tissues with no other intracranial abnormalities. Serum studies showed elevated myelin oligodendrocyte glycoprotein IgG titer. She was treated with IV methylprednisolone 1000 mg daily for 3 days and was discharged on prolonged prednisone taper with return of vision to baseline.",

keywords = "MOG IgG, headache, myelin oligodendrocyte glycoprotein, optic neuritis, trigeminal pain",

author = "Lakshmi Leishangthem and Shannon Beres and Moss, {Heather E.} and John Chen",

note = "Funding Information: Funding: This work was supported by Research to Prevent Blindness Unrestricted Grant to Stanford Department of Ophthalmology, NIH P30 026877 . Publisher Copyright: {\textcopyright} 2020",

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AU - Leishangthem, Lakshmi

AU - Beres, Shannon

AU - Moss, Heather E.

AU - Chen, John

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N2 - A 70-year-old woman presented with new onset of left eye and facial pain. Ophthalmic and neurological examinations, magnetic resonance imaging brain, erythrocyte sedimentation rate, and C-reactive protein were unrevealing. A few days later, she developed vision loss in her left eye. Examination revealed decreased visual acuity with a relative afferent pupillary defect in the left eye and a diffuse mild swelling of the left optic nerve head. Repeat magnetic resonance imaging showed T2 hyperintensity and enhancement of the intraorbital optic nerve and surrounding tissues with no other intracranial abnormalities. Serum studies showed elevated myelin oligodendrocyte glycoprotein IgG titer. She was treated with IV methylprednisolone 1000 mg daily for 3 days and was discharged on prolonged prednisone taper with return of vision to baseline.

AB - A 70-year-old woman presented with new onset of left eye and facial pain. Ophthalmic and neurological examinations, magnetic resonance imaging brain, erythrocyte sedimentation rate, and C-reactive protein were unrevealing. A few days later, she developed vision loss in her left eye. Examination revealed decreased visual acuity with a relative afferent pupillary defect in the left eye and a diffuse mild swelling of the left optic nerve head. Repeat magnetic resonance imaging showed T2 hyperintensity and enhancement of the intraorbital optic nerve and surrounding tissues with no other intracranial abnormalities. Serum studies showed elevated myelin oligodendrocyte glycoprotein IgG titer. She was treated with IV methylprednisolone 1000 mg daily for 3 days and was discharged on prolonged prednisone taper with return of vision to baseline.

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KW - myelin oligodendrocyte glycoprotein

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KW - trigeminal pain

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A tearfully painful darkness

Abstract

Keywords

ASJC Scopus subject areas

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