A step forward in the diagnosis of B-cell lymphomas in the bone marrow

Ahmet Dogan, Mine Hekimgil, Nazan Ozsan

Research output: Chapter in Book/Report/Conference proceedingChapter


Bone marrow (BM) examinations are carried out as a cornerstone procedure for diagnosis, staging and monitoring of non-Hodgkin lymphomas (NHL). This chapter will deal with the current investigations focusing on the BM findings in secondary involvement of B-cell lymphomas. Recent World Health Organization (WHO) Classification of Tumours of Haematopoietic and Lymphoid Tissues includes morphologic, immunophenotypic, cytogenetic, and molecular genetic data that define the disease entities [1]. Each entity described in this chapter will be discussed on the basis of a combination of these studies used in routine diagnosis of lymphoid malignancies. BM is occasionally examined for primary diagnosis of lymphoma patients, initial assessment of cytopenias of unknown etiology, especially when there's no accessible site of extramedullary disease or when surgical procedures are risky because of hazardous complications of anesthesia due to the general condition of the patients or diseases leading to bleeding diathesis. However, most BM examination, in the context of NHL, are performed to determine stage of disease, assessment of minimal residual disease (MRD) or relapse during follow-up, monitoring response to therapy, evaluation of hematopoietic reserve, and evaluation of pre-transplant status of patients.

Original languageEnglish (US)
Title of host publicationBone Marrow Lymphoid Infiltrates
Subtitle of host publicationDiagnosis and Clinical Impact
PublisherSpringer-Verlag London Ltd
Number of pages31
ISBN (Electronic)9781447141747
ISBN (Print)1447141733, 9781447141730
StatePublished - Nov 1 2012

ASJC Scopus subject areas

  • General Medicine


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