A simple method for noninvasive estimation of pulmonary vascular resistance

Amr E. Abbas, F. David Fortuin, Nelson B. Schiller, Christopher P. Appleton, Carlos A. Moreno, Steven J. Lester

Research output: Contribution to journalArticlepeer-review

429 Scopus citations


OBJECTIVES: We sought to test whether the ratio of peak tricuspid regurgitant velocity (TRV, ms) to the right ventricular outflow tract time-velocity integral (TVIRVOT, cm) obtained by Doppler echocardiography (TRV/TVIRVOT) provides a clinically reliable method to determine pulmonary vascular resistance (PVR). BACKGROUND: Pulmonary vascular resistance is an important hemodynamic variable used in the management of patients with cardiovascular and pulmonary disease. Right-heart catheterization, with its associated disadvantages, is required to determine PVR. However, a reliable noninvasive method is unavailable. METHODS: Simultaneous Doppler echocardiographic examination and right-heart catheterization were performed in 44 patients. The ratio of TRV/TVIRVOT was then correlated with invasive PVR measurements using regression analysis. An equation was modeled to calculate PVR in Wood units (WU) using echocardiography, and the results were compared with invasive PVR measurements using the Bland-Altman analysis. Using receiver-operating characteristics curve analysis, a cutoff value for the Doppler equation was generated to determine PVR >2WU. RESULTS: As calculated by Doppler echocardiography, TRV/TVIRVOT correlated well (r = 0.929, 95% confidence interval 0.87 to 0.96) with invasive PVR measurements. The Bland-Altman analysis between PVR obtained invasively and that by echocardiography, using the equation: PVR = TRV/TVIRVOT × 10 + 0.16, showed satisfactory limits of agreement (mean 0 ± 0.41). A TRV/TVIRVOT cutoff value of 0.175 had a sensitivity of 77% and a specificity of 81% to determine PVR >2WU. CONCLUSIONS: Doppler echocardiography may provide a reliable, noninvasive method to determine PVR.

Original languageEnglish (US)
Pages (from-to)1021-1027
Number of pages7
JournalJournal of the American College of Cardiology
Issue number6
StatePublished - Mar 19 2003

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'A simple method for noninvasive estimation of pulmonary vascular resistance'. Together they form a unique fingerprint.

Cite this