A secondary progressive clinical course is uncommon in neuromyelitis optica

D. M. Wingerchuk; S. J. Pittock; C. F. Lucchinetti; V. A. Lennon; B. G. Weinshenker

doi:10.1212/01.wnl.0000254502.87233.9a

A secondary progressive clinical course is uncommon in neuromyelitis optica

D. M. Wingerchuk, S. J. Pittock, C. F. Lucchinetti, V. A. Lennon, B. G. Weinshenker

Research output: Contribution to journal › Article › peer-review

217 Scopus citations

Abstract

We compared the clinical course of 96 patients with neuromyelitis optica (NMO) to multiple sclerosis (MS) natural history data. Based on the distribution of follow-up data (median 6.1 year), we estimated that 21 NMO patients would convert to a secondary progressive course, but we observed only two conversions (p = 0.00002; relative risk = 0.08). The disparate natural histories of MS and NMO suggest dissociation between relapses and clinical progression in CNS demyelinating diseases.

Original language	English (US)
Pages (from-to)	603-605
Number of pages	3
Journal	Neurology
Volume	68
Issue number	8
DOIs	https://doi.org/10.1212/01.wnl.0000254502.87233.9a
State	Published - Feb 2007

ASJC Scopus subject areas

Clinical Neurology

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title = "A secondary progressive clinical course is uncommon in neuromyelitis optica",

abstract = "We compared the clinical course of 96 patients with neuromyelitis optica (NMO) to multiple sclerosis (MS) natural history data. Based on the distribution of follow-up data (median 6.1 year), we estimated that 21 NMO patients would convert to a secondary progressive course, but we observed only two conversions (p = 0.00002; relative risk = 0.08). The disparate natural histories of MS and NMO suggest dissociation between relapses and clinical progression in CNS demyelinating diseases.",

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AU - Wingerchuk, D. M.

AU - Pittock, S. J.

AU - Lucchinetti, C. F.

AU - Lennon, V. A.

AU - Weinshenker, B. G.

PY - 2007/2

Y1 - 2007/2

N2 - We compared the clinical course of 96 patients with neuromyelitis optica (NMO) to multiple sclerosis (MS) natural history data. Based on the distribution of follow-up data (median 6.1 year), we estimated that 21 NMO patients would convert to a secondary progressive course, but we observed only two conversions (p = 0.00002; relative risk = 0.08). The disparate natural histories of MS and NMO suggest dissociation between relapses and clinical progression in CNS demyelinating diseases.

AB - We compared the clinical course of 96 patients with neuromyelitis optica (NMO) to multiple sclerosis (MS) natural history data. Based on the distribution of follow-up data (median 6.1 year), we estimated that 21 NMO patients would convert to a secondary progressive course, but we observed only two conversions (p = 0.00002; relative risk = 0.08). The disparate natural histories of MS and NMO suggest dissociation between relapses and clinical progression in CNS demyelinating diseases.

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A secondary progressive clinical course is uncommon in neuromyelitis optica

Abstract

ASJC Scopus subject areas

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