A preliminary study of few-view image reconstruction of sparse objects in cone-beam micro-CT

Xiao Han, Junguo Bian, Diane R. Eaker, Emil Y. Sidky, Erik L. Ritman, Xiaochnan Pan

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Micro-CT enables convenient visualization and quantitative analysis of small animals and biological tissue samples. However, high-quality volume images in general require acquisition of cone-beam projection data from hundreds of view angles. This prolonged imaging process limits system throughput and may cause potential radiation damage to the imaged objects. It is therefore desirable to have a technique which can generate volume images with satisfactory quality, but from a smaller amount of projection data. On the other hand, many objects subject to the micro-CT scans have sparse spatial distribution, and this sparcity could be exploited and incorporated as prior knowledge in innovative design of algorithms that are capable of reconstructing images from few-view projection data. In this work we applied a new iterative algorithm based upon constrained total-variation minimization to reconstructing images from as few as five projections. Preliminary results suggest that the algorithm can yield potentially useful images from substantially less projection data than required by existing algorithms. This has practical implications of reducing scanning time and minimizing radiation damage to the imaged objects.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2010
Subtitle of host publicationPhysics of Medical Imaging
EditionPART 2
StatePublished - Dec 1 2010
EventMedical Imaging 2010: Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 15 2010Feb 18 2010

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
NumberPART 2
ISSN (Print)1605-7422


OtherMedical Imaging 2010: Physics of Medical Imaging
Country/TerritoryUnited States
CitySan Diego, CA


  • Few-view image reconstruction
  • Micro-CT

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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