A phase I study of chlorozotocin (NSC 178248)

John S. Kovach, Charles G. Moertel, Allen J. Schutt, Stephen Frytak, Michael J. O'Connell, Joseph Rubin, James N. Ingle

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Chlorozotocin was administered by rapid intravenous infusion to 35 patients with advanced cancer on either single‐day or five‐consecutive‐day schedules. Total doses per course ranged from 12.5 to 200 mg/m2. On either administration schedule, dose limiting toxicities were thrombocytopenia and leukopenia at total doses of 150 mg/m2 to 200 mg/m2. Repetitive courses of drug may produce progressive impairment of renal and bone marrow function. Nausea and vomiting were infrequent and mild without definite relationship to dose. Minor reversible nondose related increases in SGOT and in serum creatinine occurred at all doses on both schedules. The plasma half‐life of intact N‐nitroso groups averaged 9.5 minutes after rapid intravenous administration of doses up to 40 mg/m2 and 12.5 minutes after doses of 150 or 200 mg/m2. No differences between plasma half‐lives were seen between identical doses given on the first and fifth days of the five‐day schedule. Objective tumor regression was noted in one patient with bronchogenic large cell carcinoma and one patient with metastatic melanoma.

Original languageEnglish (US)
Pages (from-to)2189-2196
Number of pages8
Issue number6
StatePublished - Jun 1979

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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