A novel report of cIg-FISH and cytogenetics in POEMS syndrome

Alan H. Bryce; Rhett P. Ketterling; Morie A. Gertz; Martha Lacy; Ryan A. Knudson; Shaji Kumar; Robert A. Kyle; Rafael Fonseca; Phillip R. Greipp; John A. Lust; Vincent S. Rajkumar; Suzanne R. Hayman; Francis Buadi; Stephen J. Russell; Stephen R. Zeldenrust; Angela Dispenzieri

doi:10.1002/ajh.21285

A novel report of cIg-FISH and cytogenetics in POEMS syndrome

Alan H. Bryce, Rhett P. Ketterling, Morie A. Gertz, Martha Lacy, Ryan A. Knudson, Shaji Kumar, Robert A. Kyle, Rafael Fonseca, Phillip R. Greipp, John A. Lust, Vincent S. Rajkumar, Suzanne R. Hayman, Francis Buadi, Stephen J. Russell, Stephen R. Zeldenrust, Angela Dispenzieri

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

POEMS syndrome is a plasma cell proliferative disorder whose pathogenesis is poorly understood. We provide the first report of cytoplasmic immunoglobulin/FISH testing (cIg-FISH) in POEMS syndrome using established myeloma markers. We reviewed all 37 POEMS cases seen at our institution in which cIg-FISH testing had been obtained. Monosomy 13 was seen in 14 of the 37 (38%) cIg-FISH samples. One patient had trisomy 3 and 7. Three patients had IgH translocation t(11;14)(q13;q32). No abnormalities were seen at 17p13(p53). The monosomy 13 is in line with other plasma cell disorders while the low prevalence of hyperdiploidy and abnormalities at 14q32 is unique.

Original language	English (US)
Pages (from-to)	840-841
Number of pages	2
Journal	American journal of hematology
Volume	83
Issue number	11
DOIs	https://doi.org/10.1002/ajh.21285
State	Published - Nov 2008

ASJC Scopus subject areas

Hematology

Access to Document

10.1002/ajh.21285

Cite this

Bryce, A. H., Ketterling, R. P., Gertz, M. A., Lacy, M., Knudson, R. A., Kumar, S., Kyle, R. A., Fonseca, R., Greipp, P. R., Lust, J. A., Rajkumar, V. S., Hayman, S. R., Buadi, F., Russell, S. J., Zeldenrust, S. R., & Dispenzieri, A. (2008). A novel report of cIg-FISH and cytogenetics in POEMS syndrome. American journal of hematology, 83(11), 840-841. https://doi.org/10.1002/ajh.21285

@article{35ae2c98cc6c473bbaeb1d242e09375e,

title = "A novel report of cIg-FISH and cytogenetics in POEMS syndrome",

abstract = "POEMS syndrome is a plasma cell proliferative disorder whose pathogenesis is poorly understood. We provide the first report of cytoplasmic immunoglobulin/FISH testing (cIg-FISH) in POEMS syndrome using established myeloma markers. We reviewed all 37 POEMS cases seen at our institution in which cIg-FISH testing had been obtained. Monosomy 13 was seen in 14 of the 37 (38%) cIg-FISH samples. One patient had trisomy 3 and 7. Three patients had IgH translocation t(11;14)(q13;q32). No abnormalities were seen at 17p13(p53). The monosomy 13 is in line with other plasma cell disorders while the low prevalence of hyperdiploidy and abnormalities at 14q32 is unique.",

author = "Bryce, {Alan H.} and Ketterling, {Rhett P.} and Gertz, {Morie A.} and Martha Lacy and Knudson, {Ryan A.} and Shaji Kumar and Kyle, {Robert A.} and Rafael Fonseca and Greipp, {Phillip R.} and Lust, {John A.} and Rajkumar, {Vincent S.} and Hayman, {Suzanne R.} and Francis Buadi and Russell, {Stephen J.} and Zeldenrust, {Stephen R.} and Angela Dispenzieri",

year = "2008",

month = nov,

doi = "10.1002/ajh.21285",

language = "English (US)",

volume = "83",

pages = "840--841",

journal = "American journal of hematology",

issn = "0361-8609",

publisher = "Wiley-Liss Inc.",

number = "11",

}

TY - JOUR

T1 - A novel report of cIg-FISH and cytogenetics in POEMS syndrome

AU - Bryce, Alan H.

AU - Ketterling, Rhett P.

AU - Gertz, Morie A.

AU - Lacy, Martha

AU - Knudson, Ryan A.

AU - Kumar, Shaji

AU - Kyle, Robert A.

AU - Fonseca, Rafael

AU - Greipp, Phillip R.

AU - Lust, John A.

AU - Rajkumar, Vincent S.

AU - Hayman, Suzanne R.

AU - Buadi, Francis

AU - Russell, Stephen J.

AU - Zeldenrust, Stephen R.

AU - Dispenzieri, Angela

PY - 2008/11

Y1 - 2008/11

N2 - POEMS syndrome is a plasma cell proliferative disorder whose pathogenesis is poorly understood. We provide the first report of cytoplasmic immunoglobulin/FISH testing (cIg-FISH) in POEMS syndrome using established myeloma markers. We reviewed all 37 POEMS cases seen at our institution in which cIg-FISH testing had been obtained. Monosomy 13 was seen in 14 of the 37 (38%) cIg-FISH samples. One patient had trisomy 3 and 7. Three patients had IgH translocation t(11;14)(q13;q32). No abnormalities were seen at 17p13(p53). The monosomy 13 is in line with other plasma cell disorders while the low prevalence of hyperdiploidy and abnormalities at 14q32 is unique.

AB - POEMS syndrome is a plasma cell proliferative disorder whose pathogenesis is poorly understood. We provide the first report of cytoplasmic immunoglobulin/FISH testing (cIg-FISH) in POEMS syndrome using established myeloma markers. We reviewed all 37 POEMS cases seen at our institution in which cIg-FISH testing had been obtained. Monosomy 13 was seen in 14 of the 37 (38%) cIg-FISH samples. One patient had trisomy 3 and 7. Three patients had IgH translocation t(11;14)(q13;q32). No abnormalities were seen at 17p13(p53). The monosomy 13 is in line with other plasma cell disorders while the low prevalence of hyperdiploidy and abnormalities at 14q32 is unique.

UR - http://www.scopus.com/inward/record.url?scp=55549091109&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=55549091109&partnerID=8YFLogxK

U2 - 10.1002/ajh.21285

DO - 10.1002/ajh.21285

M3 - Article

C2 - 18839437

AN - SCOPUS:55549091109

SN - 0361-8609

VL - 83

SP - 840

EP - 841

JO - American journal of hematology

JF - American journal of hematology

IS - 11

ER -

A novel report of cIg-FISH and cytogenetics in POEMS syndrome

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this