A Novel Prosthetic Joint Infection Pathogen, Mycoplasma salivarium, Identified by Metagenomic Shotgun Sequencing

Matthew Thoendel; Patricio Jeraldo; Kerryl E. Greenwood-Quaintance; Nicholas Chia; Matthew P. Abdel; James M. Steckelberg; Douglas R. Osmon; Robin Patel

doi:10.1093/cid/cix296

A Novel Prosthetic Joint Infection Pathogen, Mycoplasma salivarium, Identified by Metagenomic Shotgun Sequencing

Matthew Thoendel, Patricio Jeraldo, Kerryl E. Greenwood-Quaintance, Nicholas Chia, Matthew P. Abdel, James M. Steckelberg, Douglas R. Osmon, Robin Patel

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Defining the microbial etiology of culture-negative prosthetic joint infection (PJI) can be challenging. Metagenomic shotgun sequencing is a new tool to identify organisms undetected by conventional methods. We present a case where metagenomics was used to identify Mycoplasma salivarium as a novel PJI pathogen in a patient with hypogammaglobulinemia.

Original language	English (US)
Pages (from-to)	332-335
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	65
Issue number	2
DOIs	https://doi.org/10.1093/cid/cix296
State	Published - Jul 15 2017

Keywords

Mycoplasma
metagenomics.
prosthetic joint infection

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1093/cid/cix296

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title = "A Novel Prosthetic Joint Infection Pathogen, Mycoplasma salivarium, Identified by Metagenomic Shotgun Sequencing",

abstract = "Defining the microbial etiology of culture-negative prosthetic joint infection (PJI) can be challenging. Metagenomic shotgun sequencing is a new tool to identify organisms undetected by conventional methods. We present a case where metagenomics was used to identify Mycoplasma salivarium as a novel PJI pathogen in a patient with hypogammaglobulinemia.",

keywords = "Mycoplasma, metagenomics., prosthetic joint infection",

author = "Matthew Thoendel and Patricio Jeraldo and Greenwood-Quaintance, {Kerryl E.} and Nicholas Chia and Abdel, {Matthew P.} and Steckelberg, {James M.} and Osmon, {Douglas R.} and Robin Patel",

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language = "English (US)",

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AU - Thoendel, Matthew

AU - Jeraldo, Patricio

AU - Greenwood-Quaintance, Kerryl E.

AU - Chia, Nicholas

AU - Abdel, Matthew P.

AU - Steckelberg, James M.

AU - Osmon, Douglas R.

AU - Patel, Robin

PY - 2017/7/15

Y1 - 2017/7/15

N2 - Defining the microbial etiology of culture-negative prosthetic joint infection (PJI) can be challenging. Metagenomic shotgun sequencing is a new tool to identify organisms undetected by conventional methods. We present a case where metagenomics was used to identify Mycoplasma salivarium as a novel PJI pathogen in a patient with hypogammaglobulinemia.

AB - Defining the microbial etiology of culture-negative prosthetic joint infection (PJI) can be challenging. Metagenomic shotgun sequencing is a new tool to identify organisms undetected by conventional methods. We present a case where metagenomics was used to identify Mycoplasma salivarium as a novel PJI pathogen in a patient with hypogammaglobulinemia.

KW - Mycoplasma

KW - metagenomics.

KW - prosthetic joint infection

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JF - Clinical Infectious Diseases

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A Novel Prosthetic Joint Infection Pathogen, Mycoplasma salivarium, Identified by Metagenomic Shotgun Sequencing

Abstract

Keywords

ASJC Scopus subject areas

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