A longitudinal study of the JAK2V617F mutation in myelofibrosis with myeloid metaplasia: Analysis at two time points

Ruben A. Mesa; Heather Powell; Terra Lasho; Goron W. DeWald; Rebecca McClure; Ayalew Tefferi

A longitudinal study of the JAK2^V617F mutation in myelofibrosis with myeloid metaplasia: Analysis at two time points

Ruben A. Mesa, Heather Powell, Terra Lasho, Goron W. DeWald, Rebecca McClure, Ayalew Tefferi

Research output: Contribution to journal › Article › peer-review

Abstract

Serial analysis for the activating JAK2^V617F mutation performed in 44 patients with myelofibrosis with myeloid metaplasia showed no interval change in 88% (22/25) of patients over a median interval of 18.6 months. The increase in JAK2 expression observed in three patients did not correspond to disease progression or leukemic transformation.

Original language	English (US)
Pages (from-to)	415-416
Number of pages	2
Journal	Haematologica
Volume	91
Issue number	3
State	Published - Mar 1 2006

Keywords

JAK2
Leukemic transformation
Myelofibrosis with myeloid metaplasia
Myeloproliferative disorders

ASJC Scopus subject areas

Hematology

Cite this

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abstract = "Serial analysis for the activating JAK2V617F mutation performed in 44 patients with myelofibrosis with myeloid metaplasia showed no interval change in 88% (22/25) of patients over a median interval of 18.6 months. The increase in JAK2 expression observed in three patients did not correspond to disease progression or leukemic transformation.",

keywords = "JAK2, Leukemic transformation, Myelofibrosis with myeloid metaplasia, Myeloproliferative disorders",

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AU - DeWald, Goron W.

AU - McClure, Rebecca

AU - Tefferi, Ayalew

PY - 2006/3/1

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N2 - Serial analysis for the activating JAK2V617F mutation performed in 44 patients with myelofibrosis with myeloid metaplasia showed no interval change in 88% (22/25) of patients over a median interval of 18.6 months. The increase in JAK2 expression observed in three patients did not correspond to disease progression or leukemic transformation.

AB - Serial analysis for the activating JAK2V617F mutation performed in 44 patients with myelofibrosis with myeloid metaplasia showed no interval change in 88% (22/25) of patients over a median interval of 18.6 months. The increase in JAK2 expression observed in three patients did not correspond to disease progression or leukemic transformation.

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KW - Leukemic transformation

KW - Myelofibrosis with myeloid metaplasia

KW - Myeloproliferative disorders

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A longitudinal study of the JAK2^V617F mutation in myelofibrosis with myeloid metaplasia: Analysis at two time points

Abstract

Keywords

ASJC Scopus subject areas

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