A high-resolution imaging technique using a whole-body, research photon counting detector CT system

S. Leng, Z. Yu, A. Halaweish, S. Kappler, K. Hahn, A. Henning, Z. Li, J. Lane, D. L. Levin, S. Jorgensen, E. Ritman, C. McCollough

Research output: Chapter in Book/Report/Conference proceedingConference contribution

14 Scopus citations


A high-resolution (HR) data collection mode has been introduced to a whole-body, research photon-counting-detector CT system installed in our laboratory. In this mode, 64 rows of 0.45 mm x 0.45 mm detector pixels were used, which corresponded to a pixel size of 0.25 mm x 0.25 mm at the iso-center. Spatial resolution of this HR mode was quantified by measuring the MTF from a scan of a 50 micron wire phantom. An anthropomorphic lung phantom, cadaveric swine lung, temporal bone and heart specimens were scanned using the HR mode, and image quality was subjectively assessed by two experienced radiologists. High spatial resolution of the HR mode was evidenced by the MTF measurement, with 15 lp/cm and 20 lp/cm at 10% and 2% modulation. Images from anthropomorphic phantom and cadaveric specimens showed clear delineation of small structures, such as lung vessels, lung nodules, temporal bone structures, and coronary arteries. Temporal bone images showed critical anatomy (i.e. stapes superstructure) that was clearly visible in the PCD system. These results demonstrated the potential application of this imaging mode in lung, temporal bone, and vascular imaging. Other clinical applications that require high spatial resolution, such as musculoskeletal imaging, may also benefit from this high resolution mode.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2016
Subtitle of host publicationPhysics of Medical Imaging
EditorsDespina Kontos, Joseph Y. Lo, Thomas G. Flohr
ISBN (Electronic)9781510600188
StatePublished - 2016
EventMedical Imaging 2016: Physics of Medical Imaging - San Diego, United States
Duration: Feb 28 2016Mar 2 2016

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2016: Physics of Medical Imaging
Country/TerritoryUnited States
CitySan Diego


  • Computed tomography (CT)
  • photon counting detector (PCD)
  • spatial resolution

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging
  • Biomaterials


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