A critical role of interleukin-1 in preterm labor

Mathieu Nadeau-Vallée, Dima Obari, Christiane Quiniou, William D. Lubell, David M. Olson, Sylvie Girard, Sylvain Chemtob

Research output: Contribution to journalReview articlepeer-review


Preterm birth (PTB) is a leading cause of neonatal mortality and morbidity worldwide, and represents a heavy economic and social burden. Despite its broad etiology, PTB has been firmly linked to inflammatory processes. Pro-inflammatory cytokines are produced in gestational tissues in response to stressors and can prematurely induce uterine activation, which precedes the onset of preterm labor. Of all cytokines implicated, interleukin (IL)-1 has been largely studied, revealing a central role in preterm labor. However, currently approved IL-1-targeting therapies have failed to show expected efficacy in pre-clinical studies of preterm labor. Herein, we (a) summarize animal and human studies in which IL-1 or IL-1-targeting therapeutics are implicated with preterm labor, (b) focus on novel IL-1-targeting therapies and diagnostic tests, and (c) develop the case for commercialization and translation means to hasten their development.

Original languageEnglish (US)
Pages (from-to)37-51
Number of pages15
JournalCytokine and Growth Factor Reviews
StatePublished - Apr 1 2016


  • Infection
  • Inflammation
  • Interleukin-1
  • Preterm birth
  • Preterm labor

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • General Biochemistry, Genetics and Molecular Biology


Dive into the research topics of 'A critical role of interleukin-1 in preterm labor'. Together they form a unique fingerprint.

Cite this