@article{1f33e22570bf4026a74a63f7b87148ae,
title = "A critical role of interleukin-1 in preterm labor",
abstract = "Preterm birth (PTB) is a leading cause of neonatal mortality and morbidity worldwide, and represents a heavy economic and social burden. Despite its broad etiology, PTB has been firmly linked to inflammatory processes. Pro-inflammatory cytokines are produced in gestational tissues in response to stressors and can prematurely induce uterine activation, which precedes the onset of preterm labor. Of all cytokines implicated, interleukin (IL)-1 has been largely studied, revealing a central role in preterm labor. However, currently approved IL-1-targeting therapies have failed to show expected efficacy in pre-clinical studies of preterm labor. Herein, we (a) summarize animal and human studies in which IL-1 or IL-1-targeting therapeutics are implicated with preterm labor, (b) focus on novel IL-1-targeting therapies and diagnostic tests, and (c) develop the case for commercialization and translation means to hasten their development.",
keywords = "Infection, Inflammation, Interleukin-1, Preterm birth, Preterm labor",
author = "Mathieu Nadeau-Vall{\'e}e and Dima Obari and Christiane Quiniou and Lubell, {William D.} and Olson, {David M.} and Sylvie Girard and Sylvain Chemtob",
note = "Funding Information: We thank Dr. M{\'e}lanie Sanchez for a thorough review of this work. This study was funded by GAPPS (Global Alliance for the Prevention of Prematurity and Stillbirth, an initiative of Seattle Children{\textquoteright}s) and the Canadian Institutes of Health Research (CIHR) . M.N.V. was supported by a scholarship from the Suzanne Veronneau-Troutman Funds associated with the Department of Ophthalmology of Universit{\'e} de Montr{\'e}al, by the Vision Research Network (RRSV), by a scholarship from Fonds de Recherche en Sant{\'e} du Qu{\'e}bec (FRSQ) and by a scholarship from the CIHR. D.O. was supported by La Soci{\'e}t{\'e} Qu{\'e}b{\'e}coise d'Hypertension Art{\'e}rielle (SQHA). S.C. holds a Canada Research Chair (Vision Science), and the Leopoldine Wolfe Chair in translational research in age-related macular degeneration. Funding Information: Mathieu Nadeau-Vall{\'e}e is a PhD student in Pharmacology at Universit{\'e} de Montr{\'e}al. Highly driven, he accessed PhD straight from BSc (with Honours). Mathieu is interested in the identification of novel targets implicated in preterm birth for the development of new and safe therapeutics to prevent this condition. His most recent work describes the identification of a novel molecule to prevent preterm birth and was published in The Journal of Immunology . His researches are supported by the Canadian Institutes of Health Research (IRSC), the Fonds de Recherche en Sant{\'e} du Qu{\'e}bec (FRQS) and the Vision Health Research Network. Funding Information: Christiane Quiniou has a M.Sc. in applied microbiology from Institut Armand-Frappier and a PhD degree in Biochemistry from University of Montreal. Dr. Quiniou accumulated 15 years of experience in in vitro pharmacological characterization of allosteric modulators and conceived the rytvela (101.10) peptide. Her work was supported by the Hearth and Stroke Foundation and the Fonds de la Recherche en Sant{\'e} du Qu{\'e}bec. Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",
year = "2016",
month = apr,
day = "1",
doi = "10.1016/j.cytogfr.2015.11.001",
language = "English (US)",
volume = "28",
pages = "37--51",
journal = "Cytokine and Growth Factor Reviews",
issn = "1359-6101",
publisher = "Elsevier BV",
}