Abstract
Despite its explosive applications in genome engineering, CRISPR (Clustered Regularly Interspersed Short Palindromic Repeats) has been developed into a versatile tool beyond its well-known nuclease function. In this prospect article, we summarize a few exciting “off-label” applications of CRISPR including manipulating DNA sequences, visualizing chromosomal loci in living cells, and modulating transcription and chromatin structures. These novel applications will likely elevate CRISPR tools into yet another level of sophistication and diversity, leading to many more exciting cell biological discoveries.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1299-1308 |
| Number of pages | 10 |
| Journal | Journal of cellular biochemistry |
| Volume | 119 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2018 |
Keywords
- CRISPR
- designer nuclease
- genome engineering
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
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