@article{b36df92433d64436aa8418b51ad4becc,
title = "2016 Jeffrey M. HOEG Award lecture: Immune checkpoints in atherosclerosis: Toward immunotherapy for atheroprotection",
abstract = "Innate and adaptive immune effector mechanisms, in conjunction with hyperlipidemia, are important drivers of atherosclerosis. The interaction between the different immune cells and the secretion of cytokines and chemokines determine the progression of atherosclerosis. The activation or dampening of the immune response is tightly controlled by immune checkpoints. Costimulatory and coinhibitory immune checkpoints represent potential targets for immune modulatory therapies for atherosclerosis. This review will discuss the current knowledge on immune checkpoints in atherosclerosis and the clinical potential of immune checkpoint targeted therapy for atherosclerosis.",
keywords = "Atherosclerosis, Chemokines, Cytokines, Hyperlipidemia, Mice",
author = "Ellen Rouwet and Esther Lutgens",
note = "Funding Information: We acknowledge the support from the Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation, Dutch Federation of University Medical Centers, the Netherlands Organization for Health Research and Development, and the Royal Netherlands Academy of Sciences for the GENIUS-II (Generating the Best Evidence-Based Pharmaceutical Targets for Atherosclerosis) project Generating the best evidence-based pharmaceutical targets for atherosclerosis part II. This work was supported by the Netherlands Organization for Scientific Research (NWO; VICI grant to E. Lutgens), the European Research Council (ERC consolidator grant to E. Lutgens), the European Union (horizon 2020, REPROGRAM to E. Lutgens), and the DFG (German Research Foundation; CRC 1123, project A5 to E. Lutgens). Publisher Copyright: {\textcopyright} 2018 American Heart Association, Inc.",
year = "2018",
doi = "10.1161/ATVBAHA.118.307742",
language = "English (US)",
volume = "38",
pages = "1678--1688",
journal = "Arteriosclerosis, thrombosis, and vascular biology",
issn = "1079-5642",
publisher = "Lippincott Williams and Wilkins",
number = "8",
}