Project Details
Description
Project Narrative
Iron metabolism is tightly regulated, as iron overload can be toxic yet it is a necessary co-factor in many
enzymes including Tet dioxygenases and lysine demethylases. Disruption of iron homeostasis by deletion of
ABCB7 in lymphocytes leads to a block in B lymphopoiesis. This proposal will examine the mechanisms
behind the critical role for ABCB7 in regulating B cell development.
| Status | Finished |
|---|---|
| Effective start/end date | 3/17/21 → 2/28/23 |
Funding
- National Institute of Allergy and Infectious Diseases: $238,500.00
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.