Obesity-induced mesenchymal stem cell senescence

NARRATIVE Obesity induces chronic inflammation that triggers cellular damage involving multiple organs, including the kidney. We will test the hypothesis that in human subjects obesity induces injury to fat tissue-derived reparative cells, which interferes with their capacity to mend injured kidneys. The proposed studies may uncover novel mechanisms underlying cellular damage in human obesity, as well as the reversibility of this impairment upon weight loss.