Mayo Center for Cell Signaling in Gastroenterology

The MAIN GOAL for the Mayo Clinic Center for Cell Signaling in Gastroenterology (C-SiG) continues to be connecting discovery, translational, and patient-oriented investigators to understand and therapeutically exploit signaling pathways in gastrointestinal cells to improve the health of patients with digestive diseases. To facilitate meaningful interactions and coordinate research efforts, our Research Base is organized into three integrated Mechanistic Research Themes: i) Cellular Networks; ii) Intracellular Signaling; iii) Genetics and Epigenetics. To reflect our disease relevance, the mechanistic themes intersect with three Disease Focus Groups: i) Inflammation/Cell transformation; ii) Dysmotility and Metabolism; and iii) Liver Pathobiology. The Research Base is supported by 3 biomedical cores that foster productivity, leverage institutional resources, facilitate technology transfer, and continuously adapt their service lines to serve the members’ evolving innovative research needs in a cost-effective manner. These Cores are the: i) Microscopy & Microfluidics Core delivering sophisticated cell imaging and microfluidics capabilities; ii) Epigenomics and Spatial Biology Core providing novel epigenomics and spatial biology technologies; and iii) Clinical Core facilitating access to normal and abnormal gastrointestinal biospecimens and institutional exome sequence and digital pathology resources. Our CENTRAL HYPOTHESIS remains that advances in care of patients with digestive diseases is accelerated by a facilitative infrastructure supporting meaningful interactions among multidisciplinary scientists investigating cell signaling mechanisms, pathways, and therapeutic targets to enhance rapid translation of basic discoveries.