Alliance for Clinical Trials in Oncology Operations Center

PROJECT SUMMARY/ABSTRACT The Alliance for Clinical Trials in Oncology is an experienced multi-institutional cancer clinical trials group that develops and conducts clinical trials with promising new cancer therapies by utilizing the best science to develop optimal treatment and prevention strategies for cancer, as well as research methods to alleviate side effects of cancer and cancer treatments. The Alliance provides a comprehensive and highly efficient clinical trials infrastructure, access to experienced collaborators across all disciplines of oncology clinical trials research, and a diverse portfolio of trials for patients with breast, gastrointestinal, genitourinary, respiratory, central nervous system, hematological malignancies, in addition to rare tumors. Particular strengths of the Alliance include the long-standing tradition of collaborative research of the legacy members, its focus on science, innovation and mentorship, its successful track record in developing multidisciplinary therapeutic solutions for cancer patients, its seamless incorporation of correlative science for the discovery of prognostic and predictive biomarkers, and its commitment to special patient populations including minority and underserved populations. The Mission of the Alliance for Clinical Trials in Oncology is to reduce the impact of cancer by: • Conducting high quality multidisciplinary cancer control, prevention, and treatment trials that engage a comprehensive research network; • Furthering our understanding of the biological basis of the cancer process and its treatment; from discovery, to validation, to clinical practice; • Providing a scientific and operational infrastructure for innovative clinical and translational research in the academic and community settings.