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Dive into the research topics where Reona (Leo) Sakemura is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Targeting Cancer-Associated Fibroblasts Prevents Resistance to Chimeric Antigen Receptor T Cell Therapy
Sakemura, R. (PI)
6/7/25 → 5/31/26
Project: Research project
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Targeting Cancer-Associated Fibroblasts Prevents Resistance to Chimeric Antigen Receptor T Cell Therapy
Sakemura, R. (PI)
9/15/22 → 8/31/24
Project: Research project
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Differential susceptibility and role for senescence in CART cells based on costimulatory domains
Can, I., Siegler, E. L., Sirpilla, O. L., Manriquez-Roman, C., Yun, K., Stewart, C. M., Feigin, J. M., Rodriguez, M. L., Gutierrez-Ruiz, O. L., Ogbodo, E. J., Huynh, T. N., Kimball, B. L., Mai, L. K., Hefazi, M., Fonkoua, L. K., Xia, H., Hamaidi, I., Alkan, B., Sezer, F. & Ekiz, H. A. & 2 others, , Dec 2025, In: Molecular cancer. 24, 1, 172.Research output: Contribution to journal › Article › peer-review
Open Access -
Studying Interactions between Myeloid Cells and CAR T Cells In Vitro and In Vivo
Yun, K., Sakemura, R. L., Huynh, T. N., Kimball, B., Siegler, E. & Kenderian, S. S., Jul 2025, In: Journal of Visualized Experiments. 2025, 221, e68013.Research output: Contribution to journal › Article › peer-review
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CD19 occupancy with tafasitamab increases therapeutic index of CART19 cell therapy and diminishes severity of CRS
Sakemura, R. L., Manriquez Roman, C., Horvei, P., Siegler, E. L., Girsch, J. H., Sirpilla, O. L., Stewart, C. M., Yun, K., Can, I., Ogbodo, E. J., Adada, M. M., Bezerra, E. D., Kankeu Fonkoua, L. A., Hefazi, M., Ruff, M. W., Kimball, B. L., Mai, L. K., Huynh, T. N., Nevala, W. K. & Ilieva, K. & 11 others, , Jan 18 2024, In: Blood. 143, 3, p. 258-271 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
IL-4 drives exhaustion of CD8+ CART cells
Stewart, C. M., Siegler, E. L., Sakemura, R. L., Cox, M. J., Huynh, T., Kimball, B., Mai, L., Can, I., Manriquez Roman, C., Yun, K., Sirpilla, O., Girsch, J. H., Ogbodo, E., Mohammed Ismail, W., Gaspar-Maia, A., Budka, J., Kim, J., Scholler, N., Mattie, M. & Filosto, S. & 1 others, , Dec 2024, In: Nature communications. 15, 1, 7921.Research output: Contribution to journal › Article › peer-review
Open Access -
Mesenchymal stromal cells with chimaeric antigen receptors for enhanced immunosuppression
Sirpilla, O., Sakemura, R. L., Hefazi, M., Huynh, T. N., Can, I., Girsch, J. H., Tapper, E. E., Cox, M. J., Schick, K. J., Manriquez-Roman, C., Yun, K., Stewart, C. M., Ogbodo, E. J., Kimball, B. L., Mai, L. K., Gutierrez-Ruiz, O. L., Rodriguez, M. L., Gluscevic, M., Larson, D. P. & Abel, A. M. & 4 others, , Apr 2024, In: Nature Biomedical Engineering. 8, 4, p. 443-460 18 p.Research output: Contribution to journal › Article › peer-review