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Dive into the research topics where Leonard Petrucelli is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Leonard Petrucelli and Emmerson Michael Ward -- Ascertaining the role of TMEM106B variants in modulating tauopathy in progressivesupranuclear palsy
Petrucelli, L. (PI) & Ward, M. E. (CoPI)
1/1/25 → …
Project: Research project
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Expanding insights into FTD disease mechanisms
Petrucelli, L. (PI)
12/15/24 → 11/30/26
Project: Research project
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Investigating the role of TMEM106b genetics and pathology in Alzheimer’s disease, LATE and FTLD
Petrucelli, L. (PI) & Josephs, K. A. (CoPI)
National Institute of Neurological Disorders and Stroke
9/22/23 → 8/31/26
Project: Research project
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Discovery of novel TDP-43 splicing targets: the Achilles heel for FTD and towards sensitive biomarkers and therapeutic targets
Gitler, A. A. D. (PI), Petrucelli, L. (CoPI), Prudencio, M. (CoPI), Fratta, P. (CoPI), Prudencio, M. M. (CoPI) & Seeley, W. (CoPI)
9/15/21 → 8/31/26
Project: Research project
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Biochemical and Immunohistochemical Associations of TDP-43 and Cryptic RNA With Hippocampal and Amygdala Volumetrics in Alzheimer's Disease
Youssef, H., Gatto, R. G., Ghayal, N. B., Estades Ayuso, V., Jansen-West, K. R., Dunmore, J. A., Song, Y., Yue, M., Cook, C. N., DeTure, M., Rawlinson, B. D., Castanedes-Casey, M., Jack, C. R., Petersen, R. C., Dickson, D. W., Petrucelli, L., Whitwell, J. L., Prudencio, M. & Josephs, K. A., 2026, (Accepted/In press) In: Annals of neurology.Research output: Contribution to journal › Article › peer-review
Open Access -
Blocking RAN translation without altering repeat RNAs rescues C9ORF72-related ALS and FTD phenotypes
Jiang, X., Schaeffer, L., Patni, D., Russo, T., Lee, C. Z., Aguilar, C., Marques, C., Jansen-West, K., Hruska-Plochan, M., Ray-Soni, A., Lim, S. M., Held, A., Yue, M., Otero, P. C., Aryal, S., Beaussant, H. D. A. M., Basu, H., Takakuwa, H., Daughrity, L. M. & Ramesh, N. & 26 others, , Feb 2026, In: Science. 391, 6785, eadv2600.Research output: Contribution to journal › Article › peer-review
Open Access -
Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction
Guo, C., Chen, K., Vatsavayai, S., Akiyama, T., Liu, C., Zeng, Y., Sianto, O., Yang, E., Bombosch, J., Powell, R., Zhen, S., Mekhoubad, S., Morrie, R. D., Miller, G., Ilic, D., Boll, M., Parnell, E., Penzes, P., Lipstein, N. & Green, E. M. & 3 others, , Jun 3 2026, In: Science translational medicine. 18, 852, p. eaeb8517Research output: Contribution to journal › Article › peer-review
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FDG-PET imaging to identify brain regions associated with Alzheimer's disease-related TDP-43 proteinopathy: A predictive model using penalized logistic regression analysis
Lavrova, A., Satoh, R., Tosakulwong, N., Weigand, S. D., Jack, C. R., Petersen, R. C., Nguyen, A. T., Reichard, R. R., Prudencio, M., Petrucelli, L., Dickson, D. W., Lowe, V., Whitwell, J. L. & Josephs, K. A., Apr 2026, In: Journal of Alzheimer's Disease. 110, 3, p. 1086-1098 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Fluid and Neuroimaging Biomarkers in Microgliopathy Colony-Stimulating Factor-1 Receptor-Related Disorders
Chmiela, T., Reeves, M., Jansen-West, K., Dunmore, J., Song, Y., Strongosky, A., Gandhi, S., Pikover, G., Blurton-Jones, M., Spitale, R. C., Middlebrooks, E. H., Petrucelli, L., Prudencio, M. & Wszolek, Z. K., Jun 2026, In: Annals of Clinical and Translational Neurology. 13, 6, p. 1236-1248 13 p.Research output: Contribution to journal › Article › peer-review
Open Access