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Dive into the research topics where James L Kirkland is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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ALSENLITE: An Open-Label Pilot Study Of Senolytics For Alzheimer Disease
Kirkland, J. L. (PI)
1/1/20 → …
Project: Research project
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Targeting Cellular Senescence to Extend Healthspan
LeBrasseur, N. K. (PI), Monroe, D. D. G. (CoPI), Jurk, D. (CoPI), Ikeno, Y. (CoPI), Kirkland, J. L. (CoPI), Passos, J. (CoPI), Khosla, S. (CoPI), Pignolo, R. J. (CoPI) & Robbins, P. D. (CoPI)
6/1/19 → 1/31/27
Project: Research project
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Translational Geroscience Network
Kritchevsky, S. S. B. (CoPI), Kuchel, G. G. A. (CoPI), Kirkland, J. L. (CoPI), Kritchevsky, S. S. B. (CoPI), Tchkonia, T. T. (CoPI), Kritchevsky, S. S. B. (CoPI), Pignolo, R. R. J. (CoPI) & Tchkonia, T. (CoPI)
2/1/19 → 6/30/27
Project: Research project
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INK-ER-Cre mice: a novel tool for uncovering how senescent cells cause age-related dysfunction
Kirkland, J. L. (PI)
American Federation for Aging Research
1/1/12 → …
Project: Research project
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Los Angeles Claude D. Pepper Older Americans Independence Center
Espinoza, S. (PI), Kirkland, J. L. (CoPI), Moore, J. J. H. (CoPI), Wanagat, J. J. (CoPI), Gonzales, M. M. (CoPI), Musi, N. N. (CoPI), Cohen, P. P. (CoPI) & Cheng, S. S. (CoPI)
9/1/25 → 8/31/26
Project: Research project
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A phase II randomized placebo-controlled study of fisetin to improve physical function in breast cancer survivors: the TROFFi study rationale and trial design
Ji, J., Crespi, C. M., Yee, L., Zekster, Y. A., Al-Saleem, A., Petersen, L., Lee, C., Son, N., Smith, C., Evans, T., Tchkonia, T., Kirkland, J. L., Kuchel, G. A., Cohen, H. J. & Sedrak, M. S., Jan 1 2026, In: Therapeutic Advances in Medical Oncology. 18Research output: Contribution to journal › Article › peer-review
Open Access -
Author Correction: The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2 (Nature Cancer, (2024), 5, 3, (448-462), 10.1038/s43018-023-00712-x)
Chaib, S., López-Domínguez, J. A., Lalinde-Gutiérrez, M., Prats, N., Marin, I., Boix, O., García-Garijo, A., Meyer, K., Muñoz, M. I., Aguilera, M., Mateo, L., Stephan-Otto Attolini, C., Llanos, S., Pérez-Ramos, S., Escorihuela, M., Al-Shahrour, F., Cash, T. P., Tchkonia, T., Kirkland, J. L. & Abad, M. & 3 others, , Jul 2026, In: Nature Cancer. 7, 7, p. 1160 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Early and Late Myocardial Effects of Proton Beam Cardiac Radioablation: Insights From Gene Expression Analysis
Hirao, T., Suda, M., Rettmann, M. E., Deisher, A. J., Wight, J. A., Koya, T., Newman, L. K., Tchkonia, T., Kruse, J. J., Shumway, D. A., Merrell, K. W., Asirvatham, S. J., Kirkland, J. L., Packer, D. L. & Siontis, K. C., Mar 2026, In: JACC: Clinical Electrophysiology. 12, 3, p. 552-563 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Editorial Expression of Concern: The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice(Nature Metabolism, 10.1038/s42255-021-00491-8)
Xu, Q., Fu, Q., Li, Z., Liu, H., Wang, Y., Lin, X., He, R., Zhang, X., Ju, Z., Campisi, J., Kirkland, J. L. & Sun, Y., Mar 2026, In: Nature Metabolism. 8, 3, p. 757 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Multiomic profiling of responses to clinical and novel bisphosphonates reveals extraskeletal effects on ageing related signatures
Lu, J., Rao, S. R., Knowles, H., Zhan, H., Gamez, B., Qin, M., Platt, E., Frost, L. R., Allen, T. J., Marshall, G., Huber, K. V. M., Bauer, L. G., Vendrell, I., O’Brien, D. P., Kessler, B., Horne, A., Reid, I. R., Bountra, C., Kirkland, J. L. & Khosla, S. & 4 others, , Dec 2026, In: Signal Transduction and Targeted Therapy. 11, 1, 277.Research output: Contribution to journal › Article › peer-review
Open Access