Research output

Research output per year 1991 2011 2012 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023

• 555 Article
• 26 Review article
• 23 Comment/debate
• 9 Letter
• 4 More
  • 3 Editorial
  • 1 Chapter

Research output per year

Research output per year

Search results

• 2023

  Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry

  NBCS Collaborators, CTS Consortium & ABCTB Investigators, Dec 2023, In: Genome medicine. 15, 1, 7.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Breast Neoplasms 100%
  • Genes 63%
  • Population 61%
  • Meta-Analysis 21%
  • Cohort Studies 19%

• Association of raloxifene and tamoxifen therapy with cognitive performance, odds of mild cognitive impairment, and brain MRI markers of neurodegeneration

  Kara, F., Lohse, C. M., Castillo, A. M., Tosakulwong, N., Lesnick, T. G., Jack, C. R., Petersen, R. C., Olson, J. E., Couch, F. J., Ruddy, K. J., Kantarci, K. & Mielke, M. M., Feb 2023, In: Cancer medicine. 12, 3, p. 2805-2817 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Raloxifene Hydrochloride 100%
  • Tamoxifen 78%
  • Cognitive Behavioral Therapy 75%
  • Cognitive Dysfunction 60%
  • Magnetic Resonance Imaging 48%

• Associations of a Breast Cancer Polygenic Risk Score With Tumor Characteristics and Survival

  Lopes Cardozo, J. M. N., Andrulis, I. L., Bojesen, S. E., Dörk, T., Eccles, D. M., Fasching, P. A., Hooning, M. J., Keeman, R., Nevanlinna, H., Rutgers, E. J. T., Easton, D. F., Hall, P., Pharoah, P. D. P., Van 't Veer, L. J., Schmidt, M. K., Ahearn, T. U., Anton-Culver, H., Arndt, V., Auer, P. L., Augustinsson, A., & 147 othersBeane Freeman, L. E., Becher, H., Beckmann, M. W., Behrens, S., Benitez, J., Bermisheva, M., Blomqvist, C., Bolla, M. K., Bonanni, B., Boyle, T., Brenner, H., Brucker, S. Y., Brüning, T., Burwinkel, B., Buys, S. S., Camp, N. J., Canzian, F., Cardoso, F., Castelao, J. E., Cessna, M. H., Chan, T. L., Chang-Claude, J., Chenevix-Trench, G., Choi, J. Y., Colonna, S. V., Copson, E., Couch, F. J., Cox, A., Cross, S. S., Czene, K., Daly, M. B., Dennis, J., Devilee, P., Drukker, C. A., Dunning, A. M., Dwek, M., Eliassen, A. H., Engel, C., Evans, D. G., Figueroa, J. D., Fletcher, O., Flyger, H., Gago-Dominguez, M., García-Closas, M., García-Sáenz, J. A., Genkinger, J., Giles, G. G., González-Neira, A., Guénel, P., Gündert, M., Hahnen, E., Haiman, C. A., Håkansson, N., Hamann, U., Hartman, M., Heemskerk-Gerritsen, B. A. M., Hein, A., Ho, W. K., Hoppe, R., Hopper, J. L., Houlston, R. S., Howell, A., Hunter, D. J., Ito, H., Jakubowska, A., Jernström, H., John, E. M., Johnson, N., Jones, M. E., Joseph, V., Kaaks, R., Kang, D., Kim, S. W., Kitahara, C. M., Koppert, L. B., Kosma, V. M., Kraft, P., Kristensen, V. N., Kubelka-Sabit, K., Koutros, S., Kurian, A. W., Kwong, A., Lacey, J. V., Lambrechts, D., Le Marchand, L., Li, J., Lubiński, J., Lush, M., Mannermaa, A., Manoochehri, M., Margolin, S., Matsuo, K., Mavroudis, D., Michailidou, K., Milne, R. L., Mohd Taib, N. A., Mulligan, A. M., Neven, P., Newman, W. G., Obi, N., Offit, K., Olshan, A. F., Park, S. K., Park-Simon, T. W., Patel, A. V., Plaseska-Karanfilska, D., Poncet, C., Prentice, R. L., Presneau, N., Prevos, R., Pylkäs, K., Radice, P., Rennert, G., Rennert, H. S., Romero, A., Saloustros, E., Sawyer, E. J., Schmutzler, R. K., Schwentner, L., Scott, C., Shah, M., Shen, C. Y., Shu, X. O., Sim, X., Southey, M. C., Stone, J., Stram, D. O., Tamimi, R. M., Teo, S. H., Teras, L. R., Terry, M. B., Tomczyk, K., Tomlinson, I., Troester, M. A., Truong, T., Vachon, C. M., Van Ongeval, C., Wang, Q., Wappenschmidt, B., Wendt, C., Winqvist, R., Wolk, A., Wu, A. H., Yadav, S., Yip, C. H., Zheng, W. & Ziogas, A., Apr 1 2023, In: Journal of Clinical Oncology. 41, 10, p. 1849-1863 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Breast Neoplasms 100%
  • Survival 86%
  • Neoplasms 50%
  • Genes 9%
  • Hormones 7%

• BRCA1 frameshift variants leading to extended incorrect protein C termini

  Nepomuceno, T. C., Foo, T. K., Richardson, M. E., Ranola, J. M. O., Weyandt, J., Varga, M. J., Alarcon, A., Gutierrez, D., von Wachenfeldt, A., Eriksson, D., Kim, R., Armel, S., Iversen, E., Couch, F. J., Borg, Å., Xia, B., Carvalho, M. A. & Monteiro, A. N. A., Oct 12 2023, In: Human Genetics and Genomics Advances. 4, 4, 100240.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein C 100%
  • BRCA1 Protein 44%
  • Needs Assessment 34%
  • Homologous Recombination 33%
  • Ovarian Neoplasms 27%

• Changes in amount and intensity of physical activity over time in breast cancer survivors

  Marell, P. S., Vierkant, R. A., Olson, J. E., Herrmann, J., Larson, N. L., Lebrasseur, N. K., D'Andre, S. D., Ehlers, D. K., Stan, D. L., Cheville, A. L., Barksdale, T., Loprinzi, C. L., Couch, F. J. & Ruddy, K. J., Oct 1 2023, In: JNCI Cancer Spectrum. 7, 5, pkad056.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cancer Survivors 100%
  • Exercise 59%
  • Breast Neoplasms 58%
  • Guidelines 14%
  • Walking 13%

• Clinical outcomes and prognostic factors in triple-negative invasive lobular carcinoma of the breast

  Joshi, U., Budhathoki, P., Gaire, S., Yadav, S. K., Shah, A., Adhikari, A., Choong, G., Couzi, R., Giridhar, K. V., Leon-Ferre, R. A., Boughey, J. C., Hieken, T. J., Mutter, R., Ruddy, K. J., Haddad, T. C., Goetz, M. P., Couch, F. J. & Yadav, S., Jul 2023, In: Breast Cancer Research and Treatment. 200, 2, p. 217-224 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Lobular Carcinoma 100%
  • Breast 55%
  • Ductal Carcinoma 44%
  • Survival 28%
  • Drug Therapy 21%

• Contralateral Breast Cancer Risk among Carriers of Germline Pathogenic Variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2

  Yadav, S., Boddicker, N. J., Na, J., Polley, E. C., Hu, C., Hart, S. N., Gnanaolivu, R. D., Larson, N., Holtegaard, S., Huang, H., Dunn, C. A., Teras, L. R., Patel, A. V., Lacey, J. V., Neuhausen, S. L., Martinez, E., Haiman, C., Chen, F., Ruddy, K. J., Olson, J. E., & 16 othersJohn, E. M., Kurian, A. W., Sandler, D. P., O'Brien, K. M., Taylor, J. A., Weinberg, C. R., Anton-Culver, H., Ziogas, A., Zirpoli, G., Goldgar, D. E., Palmer, J. R., Domchek, S. M., Weitzel, J. N., Nathanson, K. L., Kraft, P. & Couch, F. J., Mar 20 2023, In: Journal of Clinical Oncology. 41, 9, p. 1703-1713 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Breast Neoplasms 100%
  • Estrogen Receptors 29%
  • Odds Ratio 13%
  • Risk Reduction Behavior 10%
  • Incidence 10%

• Distinct spatial immune microlandscapes are independently associated with outcomes in triple-negative breast cancer

  Carter, J. M., Chumsri, S., Hinerfeld, D. A., Ma, Y., Wang, X., Zahrieh, D., Hillman, D. W., Tenner, K. S., Kachergus, J. M., Brauer, H. A., Warren, S. E., Henderson, D., Shi, J., Liu, Y., Joensuu, H., Lindman, H., Leon-Ferre, R. A., Boughey, J. C., Liu, M. C., Ingle, J. N., & 6 othersKalari, K. R., Couch, F. J., Knutson, K. L., Goetz, M. P., Perez, E. A. & Thompson, E. A., Dec 2023, In: Nature communications. 14, 1, 2215.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Triple Negative Breast Neoplasms 100%
  • breast 87%
  • cancer 77%
  • biomarkers 55%
  • Biological Marker 49%

• Financial hardship in breast cancer survivors: a prospective analysis of change in financial concerns over time

  Storandt, M. H., Durani, U., Stan, D., Larson, N., Loprinzi, C., Couch, F., Olson, J. E., Khera, N. & Ruddy, K. J., Jan 2023, In: Supportive Care in Cancer. 31, 1, 62.

  Research output: Contribution to journal › Article › peer-review

  • Cancer Survivors 100%
  • Breast Neoplasms 58%
  • Breast Diseases 28%
  • Survivors 20%
  • Registries 18%

• Germline Mutations in 12 Genes and Risk of Ovarian Cancer in Three Population-Based Cohorts

  Kotsopoulos, J., Hathaway, C. A., Narod, S. A., Teras, L. R., Patel, A. V., Hu, C., Yadav, S., Couch, F. J. & Tworoger, S. S., Oct 1 2023, In: Cancer Epidemiology Biomarkers and Prevention. 32, 10, p. 1402-1410 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Germ-Line Mutation 100%
  • Ovarian Neoplasms 80%
  • Odds Ratio 57%
  • Mutation 41%
  • Genes 35%

• MacroH2A histone variants modulate enhancer activity to repress oncogenic programs and cellular reprogramming

  Mohammed Ismail, W., Mazzone, A., Ghiraldini, F. G., Kaur, J., Bains, M., Munankarmy, A., Bagwell, M. S., Safgren, S. L., Moore-Weiss, J., Buciuc, M., Shimp, L., Leach, K. A., Duarte, L. F., Nagi, C. S., Carcamo, S., Chung, C. Y., Hasson, D., Dadgar, N., Zhong, J., Lee, J. H., & 5 othersCouch, F. J., Revzin, A., Ordog, T., Bernstein, E. & Gaspar-Maia, A., Dec 2023, In: Communications Biology. 6, 1, 215.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • macroH2A histone 100%
  • Oncogenic 73%
  • Cellular Reprogramming 67%
  • Enhancer 62%
  • Histone 56%

• Multiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis

  AURORA US Network, Jan 2023, In: Nature Cancer. 4, 1, p. 128-147 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Epigenomics 100%
  • Breast Neoplasms 73%
  • Neoplasm Metastasis 70%
  • DNA Methylation 32%
  • Estrogen Receptors 30%

• NBN Pathogenic Germline Variants are Associated with Pan-Cancer Susceptibility and In Vitro DNA Damage Response Defects

  Belhadj, S., Khurram, A., Bandlamudi, C., Palou-Márquez, G., Ravichandran, V., Steinsnyder, Z., Wildman, T., Catchings, A., Kemel, Y., Mukherjee, S., Fesko, B., Arora, K., Mehine, M., Dandiker, S., Izhar, A., Petrini, J., Domchek, S., Nathanson, K. L., Brower, J., Couch, F., & 9 othersStadler, Z., Robson, M., Walsh, M., Vijai, J., Berger, M., Supek, F., Karam, R., Topka, S. & Offit, K., Jan 15 2023, In: Clinical Cancer Research. 29, 2, p. 422-431 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA Damage 100%
  • In Vitro Techniques 50%
  • Neoplasms 37%
  • Confidence Intervals 34%
  • Alleles 20%

• PDJ amplicon in triple negative breast cancer

  Roesler, A. S., Malasi, S., Koslosky, L., Hartmayer, P., Naab, T. J., Carter, J. M., Zahrieh, D., Hillman, D., Leon-Ferre, R. A., Couch, F. J., Goetz, M. P., Anderson, K. S., Pockaj, B. A. & Barrett, M. T., Dec 2023, In: Scientific reports. 13, 1, 618.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Triple Negative Breast Neoplasms 100%
  • Hospital Distribution Systems 16%
  • Tumor-Infiltrating Lymphocytes 15%
  • Neoadjuvant Therapy 13%
  • Fluorescence In Situ Hybridization 11%

• Prognostic stratification of endometrial cancers with high microsatellite instability or no specific molecular profile

  Gonzalez-Bosquet, J., Weroha, S. J., Bakkum-Gamez, J. N., Weaver, A. L., McGree, M. E., Dowdy, S. C., Famuyide, A. O., Kipp, B. R., Halling, K. C., Yadav, S., Couch, F. J. & Podratz, K. C., 2023, In: Frontiers in Oncology. 13, 1105504.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Microsatellite Instability 100%
  • Endometrial Neoplasms 83%
  • Homologous Recombination 22%
  • Disease-Free Survival 9%
  • Genes 8%

• Sexual Dysfunction in Patients With Metastatic Breast Cancer

  Jahan, N., Cathcart-Rake, E., Vierkant, R. A., Larson, N., Loprinzi, C., O'Sullivan, C. C., Faubion, S., Kuhle, C., Vencill, J. A., Couch, F., Olson, J. E. & Ruddy, K. J., 2023, (Accepted/In press) In: Clinical breast cancer.

  Research output: Contribution to journal › Article › peer-review

• Summary of the experiences, knowledge, medical management, and family communication of monoallelic MUTYH carriers

  McKenna, D. B., Sanchez, P., Powers, J., Brower, J., Wang, L., Mueller, R., Symecko, H., Hamilton, J. G., Wildman, T., Domchek, S. M., Couch, F. J., Garber, J. E., Offit, K., Robson, M. E. & Katona, B. W., Apr 2023, In: Journal of Genetic Counseling. 32, 2, p. 342-350 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Knowledge Management 100%
  • Communication 55%
  • Genetic Testing 30%
  • Neoplasms 23%
  • Registries 23%
• 2022

  A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis

  RENACER, Mar 7 2022, In: EMBO Molecular Medicine. 14, 3, e14552.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Preclinical Drug Evaluations 100%
  • Neoplasm Metastasis 52%
  • Brain 41%
  • Neurosurgery 15%
  • Disease Management 13%

• An integrative model for the comprehensive classification of BRCA1 and BRCA2 variants of uncertain clinical significance

  Iversen, E. S., Lipton, G., Hart, S. N., Lee, K. Y., Hu, C., Polley, E. C., Pesaran, T., Yussuf, A., LaDuca, H., Chao, E., Karam, R., Goldgar, D. E., Couch, F. J. & Monteiro, A. N. A., Dec 2022, In: npj Genomic Medicine. 7, 1, 35.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • BRCA2 Gene 100%
  • Statistical Models 78%
  • Risk Management 76%
  • Computer Simulation 65%
  • Ovarian Neoplasms 63%

• Assessment of small in-frame indels and C-terminal nonsense variants of BRCA1 using a validated functional assay

  Nepomuceno, T. C., dos Santos, A. P. P., Fernandes, V. C., Elias, A. B. R., Gomes, T. T., Suarez-Kurtz, G., Iversen, E. S., Couch, F. J., Monteiro, A. N. A. & Carvalho, M. A., Dec 2022, In: Scientific reports. 12, 1, 16203.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Breast Neoplasms 100%
  • Statistical Models 87%
  • Amino Acid Substitution 85%
  • Codon 77%
  • Ovarian Neoplasms 71%

• Bilateral Oophorectomy and the Risk of Breast Cancer in BRCA1 Mutation Carriers: A Reappraisal

  the Hereditary Breast Cancer Clinical Study Group, Jul 2022, In: Cancer Epidemiology Biomarkers and Prevention. 31, 7, p. 1351-1358 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ovariectomy 100%
  • Breast Neoplasms 57%
  • Mutation 50%
  • Odds Ratio 28%
  • Confidence Intervals 20%

• Breast and Prostate Cancer Risks for Male BRCA1 and BRCA2 Pathogenic Variant Carriers Using Polygenic Risk Scores

  Barnes, D. R., Silvestri, V., Leslie, G., McGuffog, L., Dennis, J., Yang, X., Adlard, J., Agnarsson, B. A., Ahmed, M., Aittomaki, K., Andrulis, I. L., Arason, A., Arnold, N., Auber, B., Azzollini, J., Balmana, J., Barkardottir, R. B., Barrowdale, D., Barwell, J., Belotti, M., & 144 othersBenitez, J., Berthet, P., Boonen, S. E., Borg, A., Bozsik, A., Brady, A. F., Brennan, P., Brewer, C., Brunet, J., Bucalo, A., Buys, S. S., Caldes, T., Caligo, M. A., Campbell, I., Cassingham, H., Christensen, L. L., Cini, G., Claes, K. B. M., Cook, J., Coppa, A., Cortesi, L., Damante, G., Darder, E., Davidson, R., De La Hoya, M., De Leeneer, K., De Putter, R., Del Valle, J., Diez, O., Ding, Y. C., Domchek, S. M., Donaldson, A., Eason, J., Eeles, R., Engel, C., Evans, D. G., Feliubadalo, L., Fostira, F., Frone, M., Frost, D., Gallagher, D., Gehrig, A., Giraud, S., Glendon, G., Godwin, A. K., Goldgar, D. E., Greene, M. H., Gregory, H., Gross, E., Hahnen, E., Hamann, U., Hansen, T. V. O., Hanson, H., Hentschel, J., Horvath, J., Izatt, L., Izquierdo, A., James, P. A., Janavicius, R., Jensen, U. B., Johannsson, O. T., John, E. M., Kramer, G., Kroeldrup, L., Kruse, T. A., Lautrup, C., Lazaro, C., Lesueur, F., Lopez-Fernandez, A., Mai, P. L., Manoukian, S., Matrai, Z., Matricardi, L., Maxwell, K. N., Mebirouk, N., Meindl, A., Montagna, M., Monteiro, A. N., Morrison, P. J., Muranen, T. A., Murray, A., Nathanson, K. L., Neuhausen, S. L., Nevanlinna, H., Nguyen-Dumont, T., Niederacher, D., Olah, E., Olopade, O. I., Palli, D., Parsons, M. T., Pedersen, I. S., Peissel, B., Perez-Segura, P., Peterlongo, P., Petersen, A. H., Pinto, P., Porteous, M. E., Pottinger, C., Pujana, M. A., Radice, P., Ramser, J., Rantala, J., Robson, M., Rogers, M. T., Rønlund, K., Rump, A., Sanchez De Abajo, A. M., Shah, P. D., Sharif, S., Side, L. E., Singer, C. F., Stadler, Z., Steele, L., Stoppa-Lyonnet, D., Sutter, C., Tan, Y. Y., Teixeira, M. R., Teule, A., Thull, D. L., Tischkowitz, M., Toland, A. E., Tommasi, S., Toss, A., Trainer, A. H., Tripathi, V., Valentini, V., Van Asperen, C. J., Venturelli, M., Viel, A., Vijai, J., Walker, L., Wang-Gohrke, S., Wappenschmidt, B., Whaite, A., Zanna, I., Offit, K., Thomassen, M., Couch, F. J., Schmutzler, R. K., Simard, J., Easton, D. F., Chenevix-Trench, G., Antoniou, A. C. & Ottini, L., Jan 1 2022, In: Journal of the National Cancer Institute. 114, 1, p. 109-122 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Prostatic Neoplasms 100%
  • Breast Neoplasms 80%
  • Odds Ratio 21%
  • Confidence Intervals 20%
  • Estrogen Receptors 15%

• Breast Cancer Screening Strategies for Women with ATM, CHEK2, and PALB2 Pathogenic Variants: A Comparative Modeling Analysis

  Lowry, K. P., Geuzinge, H. A., Stout, N. K., Alagoz, O., Hampton, J., Kerlikowske, K., De Koning, H. J., Miglioretti, D. L., Van Ravesteyn, N. T., Schechter, C., Sprague, B. L., Tosteson, A. N. A., Trentham-Dietz, A., Weaver, D., Yaffe, M. J., Yeh, J. M., Couch, F. J., Hu, C., Kraft, P., Polley, E. C., & 3 othersMandelblatt, J. S., Kurian, A. W. & Robson, M. E., Apr 2022, In: JAMA Oncology. 8, 4, p. 587-596 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Early Detection of Cancer 100%
  • Mammography 93%
  • Magnetic Resonance Imaging 69%
  • Breast Neoplasms 67%
  • Mortality 26%

• CDK5RAP3, a New BRCA2 Partner That Regulates DNA Repair, Is Associated with Breast Cancer Survival

  Minguillón, J., Ramírez, M. J., Rovirosa, L., Bustamante-Madrid, P., Camps-Fajol, C., De Garibay, G. R., Shimelis, H., Montanuy, H., Pujol, R., Hernandez, G., Bogliolo, M., Castillo, P., Soucy, P., Martrat, G., Gómez, A., Cuadras, D., García, M. J., Gayarre, J., Lázaro, C., Benítez, J., & 3 othersCouch, F. J., Angel Pujana, M. & Surrallés, J., Jan 1 2022, In: Cancers. 14, 2, 353.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA Repair 100%
  • DNA Damage 70%
  • Breast Neoplasms 68%
  • Survival 59%
  • Genomic Instability 59%

• Classification of BRCA2 Variants of Uncertain Significance (VUS) Using an ACMG/AMP Model Incorporating a Homology-Directed Repair (HDR) Functional Assay

  Hu, C., Susswein, L. R., Roberts, M. E., Yang, H., Marshall, M. L., Hiraki, S., Berkofsky-Fessler, W., Gupta, S., Shen, W., Dunn, C. A., Huang, H., Na, J., Domchek, S. M., Yadav, S., Monteiro, A. N. A., Polley, E. C., Hart, S. N., Hruska, K. S. & Couch, F. J., Sep 1 2022, In: Clinical Cancer Research. 28, 17, p. 3742-3751 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Adenosine Monophosphate 100%
  • BRCA2 Gene 32%
  • BRCA1 Gene 30%
  • Medical Genetics 30%
  • Double-Stranded DNA Breaks 25%

• Common variants in breast cancer risk loci predispose to distinct tumor subtypes

  NBCS Collaborators, ABCTB Investigators & kConFab/AOCS Investigators, Dec 1 2022, In: Breast Cancer Research. 24, 1, 2.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Breast Neoplasms 100%
  • Estrogen Receptors 87%
  • human ERBB2 protein 76%
  • Progesterone Receptors 65%
  • Genome-Wide Association Study 65%

• Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers

  GEMO Study Collaborators, EMBRACE Collaborators, SWE-BRCA Investigators, KConFab investigators & HEBON Investigators, Dec 2022, In: Communications Biology. 5, 1, 1061.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • modifiers (genes) 100%
  • breast neoplasms 91%
  • Breast Neoplasms 51%
  • Modifier Genes 28%
  • risk estimate 28%

• ECPPF (E2F1, CCNA2, POLE, PPP2R1A, FBXW7) stratification: Profiling high-risk subtypes of histomorphologically low-risk and treatment-insensitive endometrioid endometrial cancer

  Gonzalez-Bosquet, J., John Weroha, S., Bakkum-Gamez, J. N., Weaver, A. L., McGree, M. E., Dowdy, S. C., Famuyide, A. O., Kipp, B. R., Halling, K. C., Yadav, S., Couch, F. J. & Podratz, K. C., Dec 2022, In: PloS one. 17, 12 December, e0278408.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Endometrial Neoplasms 100%
  • Progression-Free Survival 19%
  • Therapeutics 15%
  • Treatment Failure 10%
  • Recurrence 9%

• Erratum: Correction: Polygenic risk modeling for prediction of epithelial ovarian cancer risk (European journal of human genetics : EJHG (2022) 30 3 (349-362))

  GEMO Study Collaborators, GC-HBOC Study Collaborators, EMBRACE Collaborators, OPAL study group, AOCS Group, KConFab investigators, HEBON Investigators, OCAC Consortium & CIMBA Consortium, May 1 2022, In: European Journal of Human Genetics. 30, 5, p. 630-631 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

• Erratum: Risks of breast and ovarian cancer for women harboring pathogenic missense variants in BRCA1 and BRCA2 compared with those harboring protein truncating variants (Genetics in Medicine (2022) 24(1) (119–129), (S1098360021011308), (10.1016/j.gim.2021.08.016))

  ENIGMA Consortium and CIMBA Consortium, Oct 2022, In: Genetics in Medicine. 24, 10, p. 2208 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Viverridae 100%
  • Ovarian Neoplasms 64%
  • Medicine 51%
  • Breast Neoplasms 45%
  • Proteins 26%

• Estrogen receptor beta repurposes EZH2 to suppress oncogenic NFκB/p65 signaling in triple negative breast cancer

  Aspros, K. G. M., Carter, J. M., Hoskin, T. L., Suman, V. J., Subramaniam, M., Emch, M. J., Ye, Z., Sun, Z., Sinnwell, J. P., Thompson, K. J., Tang, X., Rodman, E. P. B., Wang, X., Nelson, A. W., Chernukhin, I., Hamdan, F. H., Bruinsma, E. S., Carroll, J. S., Fernandez-Zapico, M. E., Johnsen, S. A., & 7 othersKalari, K. R., Huang, H., Leon-Ferre, R. A., Couch, F. J., Ingle, J. N., Goetz, M. P. & Hawse, J. R., Dec 2022, In: npj Breast Cancer. 8, 1, 20.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Estrogen Receptor beta 100%
  • Triple Negative Breast Neoplasms 94%
  • Enhancer of Zeste Homolog 2 Protein 13%
  • Polycomb Repressive Complex 2 13%
  • Neoplasms 11%

• Factors Associated With Physical Activity Levels in Patients With Breast Cancer

  Marell, P. S., Vierkant, R. A., Olson, J. E., Herrmann, J., Larson, N., LeBrasseur, N. K., D'Andre, S. D., Cheville, A. L., Barksdale, T., Loprinzi, C. L., Couch, F. & Ruddy, K. J., Oct 2022, In: Oncologist. 27, 10, p. E811-E814

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Exercise 100%
  • Breast Neoplasms 98%
  • Guidelines 37%
  • Mastectomy 21%
  • Cancer Survivors 21%

• First international workshop of the ATM and cancer risk group (4-5 December 2019)

  Spanish ATM working group, GC-HBOC & CARRIERS and Ambry Groups, Apr 2022, In: Familial Cancer. 21, 2, p. 211-227 17 p.

  Research output: Contribution to journal › Review article › peer-review

  • Ataxia Telangiectasia 100%
  • Ataxia-Telangiectasia Variant 76%
  • Education 49%
  • Neoplasms 25%
  • Epidemiologists 17%

• Genetic Risk of Second Primary Cancer in Breast Cancer Survivors: The Multiethnic Cohort Study

  Chen, F., Park, S. L., Wilkens, L. R., Wan, P., Hart, S. N., Hu, C., Yadav, S., Couch, F. J., Conti, D. V., de Smith, A. J. & Haiman, C. A., Sep 15 2022, In: Cancer research. 82, 18, p. 3201-3208 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Second Primary Neoplasms 100%
  • Cancer Survivors 95%
  • Cohort Studies 59%
  • Breast Neoplasms 55%
  • Oceanic Ancestry Group 12%

• Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci

  NBCS Investigators, Dec 2022, In: Breast Cancer Research. 24, 1, 27.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Breast Density 100%
  • Transcriptome 67%
  • Genome 49%
  • Phenotype 43%
  • Breast Neoplasms 23%

• Genome-wide interaction analysis of menopausal hormone therapy use and breast cancer risk among 62,370 women

  Wang, X., Kapoor, P. M., Auer, P. L., Dennis, J., Dunning, A. M., Wang, Q., Lush, M., Michailidou, K., Bolla, M. K., Aronson, K. J., Murphy, R. A., Brooks-Wilson, A., Lee, D. G., Cordina-Duverger, E., Guénel, P., Truong, T., Mulot, C., Teras, L. R., Patel, A. V., Dossus, L., & 60 othersKaaks, R., Hoppe, R., Lo, W. Y., Brüning, T., Hamann, U., Czene, K., Gabrielson, M., Hall, P., Eriksson, M., Jung, A., Becher, H., Couch, F. J., Larson, N. L., Olson, J. E., Ruddy, K. J., Giles, G. G., MacInnis, R. J., Southey, M. C., Le Marchand, L., Wilkens, L. R., Haiman, C. A., Olsson, H., Augustinsson, A., Krüger, U., Wagner, P., Scott, C., Winham, S. J., Vachon, C. M., Perou, C. M., Olshan, A. F., Troester, M. A., Hunter, D. J., Eliassen, H. A., Tamimi, R. M., Brantley, K., Andrulis, I. L., Figueroa, J., Chanock, S. J., Ahearn, T. U., García-Closas, M., Evans, G. D., Newman, W. G., van Veen, E. M., Howell, A., Wolk, A., Håkansson, N., Anton-Culver, H., Ziogas, A., Jones, M. E., Orr, N., Schoemaker, M. J., Swerdlow, A. J., Kitahara, C. M., Linet, M., Prentice, R. L., Easton, D. F., Milne, R. L., Kraft, P., Chang-Claude, J. & Lindström, S., Dec 2022, In: Scientific reports. 12, 1, 6199.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hormones 100%
  • Genome 96%
  • Breast Neoplasms 90%
  • Therapeutics 23%
  • Logistic Models 23%

• Incorporating progesterone receptor expression into the PREDICT breast prognostic model

  ABCTB Investigators, KConFab investigators & KConFab investigators, Sep 2022, In: European Journal of Cancer. 173, p. 178-193 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Progesterone Receptors 100%
  • Breast 72%
  • Breast Neoplasms 60%
  • New Zealand 32%
  • Calibration 32%

• Influence of Cancer Susceptibility Gene Mutations and ABO Blood Group of Pancreatic Cancer Probands on Concomitant Risk to First-Degree Relatives

  Antwi, S. O., Rabe, K. G., Bamlet, W. R., Meyer, M., Chandra, S., Fagan, S. E., Hu, C., Couch, F. J., McWilliams, R. R., Oberg, A. L. & Petersen, G. M., Feb 2022, In: Cancer Epidemiology Biomarkers and Prevention. 31, 2, p. 372-381 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neoplasm Genes 100%
  • Blood Group Antigens 99%
  • Pancreatic Neoplasms 87%
  • Confidence Intervals 55%
  • Mutation 51%

• Luminal androgen receptor breast cancer subtype and investigation of the microenvironment and neoadjuvant chemotherapy response

  Thompson, K. J., Leon-Ferre, R. A., Sinnwell, J. P., Zahrieh, D. M., Suman, V. J., Metzger, F. O., Asad, S., Stover, D. G., Carey, L., Sikov, W. M., Ingle, J. N., Liu, M. C., Carter, J. M., Klee, E. W., Weinshilboum, R. M., Boughey, J. C., Wang, L., Couch, F. J., Goetz, M. P. & Kalari, K. R., Jun 1 2022, In: NAR Cancer. 4, 2, zcac018.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Androgen Receptors 100%
  • Triple Negative Breast Neoplasms 98%
  • Breast Neoplasms 59%
  • Drug Therapy 54%
  • Tumor-Infiltrating Lymphocytes 14%

• Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities

  Cosgrove, N., Varešlija, D., Keelan, S., Elangovan, A., Atkinson, J. M., Cocchiglia, S., Bane, F. T., Singh, V., Furney, S., Hu, C., Carter, J. M., Hart, S. N., Yadav, S., Goetz, M. P., Hill, A. D. K., Oesterreich, S., Lee, A. V., Couch, F. J. & Young, L. S., Dec 2022, In: Nature communications. 13, 1, 514.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • metastasis 100%
  • vulnerability 95%
  • Plastic Property 79%
  • breast 72%
  • brain 65%

• Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts

  Strand, S. H., Rivero-Gutiérrez, B., Houlahan, K. E., Seoane, J. A., King, L. M., Risom, T., Simpson, L. A., Vennam, S., Khan, A., Cisneros, L., Hardman, T., Harmon, B., Couch, F., Gallagher, K., Kilgore, M., Wei, S., DeMichele, A., King, T., McAuliffe, P. F., Nangia, J., & 32 othersLee, J., Tseng, J., Storniolo, A. M., Thompson, A. M., Gupta, G. P., Burns, R., Veis, D. J., DeSchryver, K., Zhu, C., Matusiak, M., Wang, J., Zhu, S. X., Tappenden, J., Ding, D. Y., Zhang, D., Luo, J., Jiang, S., Varma, S., Anderson, L., Straub, C., Srivastava, S., Curtis, C., Tibshirani, R., Angelo, R. M., Hall, A., Owzar, K., Polyak, K., Maley, C., Marks, J. R., Colditz, G. A., Hwang, E. S. & West, R. B., Dec 12 2022, In: Cancer cell. 40, 12, p. 1521-1536.e7

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Breast Carcinoma In Situ 100%
  • Carcinoma, Intraductal, Noninfiltrating 82%
  • Biomarkers 45%
  • Breast Neoplasms 33%
  • Recurrence 29%

• Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study

  Dixon-Suen, S. C., Lewis, S. J., Martin, R. M., English, D. R., Boyle, T., Giles, G. G., Michailidou, K., Bolla, M. K., Wang, Q., Dennis, J., Lush, M., Investigators, A., Ahearn, T. U., Ambrosone, C. B., Andrulis, I. L., Anton-Culver, H., Arndt, V., Aronson, K. J., Augustinsson, A., Auvinen, P., & 138 othersFreeman, L. E. B., Becher, H., Beckmann, M. W., Behrens, S., Bermisheva, M., Blomqvist, C., Bogdanova, N. V., Bojesen, S. E., Bonanni, B., Brenner, H., Brüning, T., Buys, S. S., Camp, N. J., Campa, D., Canzian, F., Castelao, J. E., Cessna, M. H., Chang-Claude, J., Chanock, S. J., Clarke, C. L., Conroy, D. M., Couch, F. J., Cox, A., Cross, S. S., Czene, K., Daly, M. B., Devilee, P., Dörk, T., Dwek, M., Eccles, D. M., Eliassen, A. H., Engel, C., Eriksson, M., Evans, D. G., Fasching, P. A., Fletcher, O., Flyger, H., Fritschi, L., Gabrielson, M., Gago-Dominguez, M., García-Closas, M., García-Sáenz, J. A., Goldberg, M. S., Guénel, P., Gündert, M., Hahnen, E., Haiman, C. A., Häberle, L., Håkansson, N., Hall, P., Hamann, U., Hart, S. N., Harvie, M., Hillemanns, P., Hollestelle, A., Hooning, M. J., Hoppe, R., Hopper, J., Howell, A., Hunter, D. J., Jakubowska, A., Janni, W., John, E. M., Jung, A., Kaaks, R., Keeman, R., Kitahara, C. M., Koutros, S., Kraft, P., Kristensen, V. N., Kubelka-Sabit, K., Kurian, A. W., Lacey, J. V., Lambrechts, D., Le Marchand, L., Lindblom, A., Loibl, S., Lubiński, J., Mannermaa, A., Manoochehri, M., Margolin, S., Martinez, M. E., Mavroudis, D., Menon, U., Mulligan, A. M., Murphy, R. A., Collaborators, N., Nevanlinna, H., Nevelsteen, I., Newman, W. G., Offit, K., Olshan, A. F., Olsson, H., Orr, N., Patel, A., Peto, J., Plaseska-Karanfilska, D., Presneau, N., Rack, B., Radice, P., Rees-Punia, E., Rennert, G., Rennert, H. S., Romero, A., Saloustros, E., Sandler, D. P., Schmidt, M. K., Schmutzler, R. K., Schwentner, L., Scott, C., Shah, M., Shu, X. O., Simard, J., Southey, M. C., Stone, J., Surowy, H., Swerdlow, A. J., Tamimi, R. M., Tapper, W. J., Taylor, J. A., Terry, M. B., Tollenaar, R. A. E. M., Troester, M. A., Truong, T., Untch, M., Vachon, C. M., Joseph, V., Wappenschmidt, B., Weinberg, C. R., Wolk, A., Yannoukakos, D., Zheng, W., Ziogas, A., Dunning, A. M., Pharoah, P. D. P., Easton, D. F., Milne, R. L. & Lynch, B. M., Sep 6 2022, In: British journal of sports medicine. 56, 20, p. 1157-1170 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Random Allocation 100%
  • Exercise 66%
  • Breast Neoplasms 65%
  • Sedentary Behavior 36%
  • Causality 31%

• Polygenic risk modeling for prediction of epithelial ovarian cancer risk

  GEMO Study Collaborators, GC-HBOC Study Collaborators, EMBRACE Collaborators, OPAL study group, AOCS Group, KConFab investigators, HEBON Investigators, The OCAC Consortium & the Cimba Consortium, Mar 2022, In: European Journal of Human Genetics. 30, 3, p. 349-362 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ovarian Epithelial Carcinoma 100%
  • Ovarian Neoplasms 56%
  • Area Under Curve 50%
  • Single Nucleotide Polymorphism 20%
  • Logistic Models 16%

• Rare germline copy number variants (CNVs) and breast cancer risk

  NBCS Collaborators, CTS Consortium, ABCTB Investigators & kConFab/AOCS Investigators, Dec 2022, In: Communications Biology. 5, 1, 65.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • breast neoplasms 100%
  • Size Effect 98%
  • germ cells 73%
  • Breast Neoplasms 55%
  • Genes 35%

• Rare germline variants in PALB2 and BRCA2 in familial and sporadic chordoma

  Xia, B., Biswas, K., Foo, T. K., Gomes, T. T., Riedel-Topper, M., Southon, E., Kang, Z., Huo, Y., Reid, S., Stauffer, S., Zhou, W., Zhu, B., Koka, H., Yepes, S., Brodie, S. A., Jones, K., Vogt, A., Carter, B., Freedman, N. D., Hicks, B., & 9 othersYeager, M., Chanock, S. J., Couch, F., Parry, D. M., Monteiro, A. N., Goldstein, A. M., Carvalho, M. A., Sharan, S. K. & Yang, X. R., Oct 1 2022, In: Human mutation. 43, 10, p. 1396-1407 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chordoma 100%
  • Homologous Recombination 37%
  • Brachyury protein 12%
  • Notochord 11%
  • Poly(ADP-ribose) Polymerase Inhibitors 10%

• Reproductive risk factors associated with breast cancer in young women by molecular subtype

  Ruddy, K. J., Vierkant, R. A., Jahan, N., Higgins, A., Partridge, A., Larson, N., Radisky, D. C., Couch, F., Olson, J. & Sherman, M. E., Dec 2022, In: Breast. 66, p. 272-277 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Breast Neoplasms 100%
  • Breast Diseases 55%
  • Postpartum Period 42%
  • Registries 35%
  • Logistic Models 29%

• Risks of breast and ovarian cancer for women harboring pathogenic missense variants in BRCA1 and BRCA2 compared with those harboring protein truncating variants

  ENIGMA Consortium & CIMBA Consortium, Jan 2022, In: Genetics in Medicine. 24, 1, p. 119-129 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ovarian Neoplasms 100%
  • Pedigree 96%
  • Breast Neoplasms 70%
  • Proteins 40%
  • BRCA1 Protein 32%

• Surveillance mammography after treatment for male breast cancer

  Yadav, S., Sangaralingham, L., Payne, S. R., Giridhar, K. V., Hieken, T. J., Boughey, J. C., Mutter, R. W., Hawse, J. R., Jimenez, R. E., Freedman, R. A., Khanani, S., Couch, F. J., Vachon, C., Shah, N., Leon-Ferre, R. A. & Ruddy, K. J., Aug 2022, In: Breast Cancer Research and Treatment. 194, 3, p. 693-698 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Male Breast Neoplasms 100%
  • Mammography 74%
  • Segmental Mastectomy 28%
  • Cancer Survivors 20%
  • Insurance Coverage 14%

• Surveillance mammography in older breast cancer survivors: Current practice patterns and patient perceptions

  Karam, D., Vierkant, R. A., Ehlers, S., Freedman, R. A., Austin, J., Khanani, S., Larson, N. L., Loprinzi, C. L., Couch, F., Olson, J. E. & Ruddy, K. J., Sep 2022, In: Journal of Geriatric Oncology. 13, 7, p. 1038-1042 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Cancer Survivors 100%
  • Mammography 97%
  • Breast Neoplasms 58%
  • Breast Diseases 16%
  • Mastectomy 14%

• The risks of cancer in older women with BRCA pathogenic variants: How far have we come?

  Metcalfe, K. A., Gronwald, J., Tung, N. M., McCuaig, J. M., Eisen, A., Elser, C., Foulkes, W. D., Neuhausen, S. L., Senter, L., Moller, P., Bordeleau, L., Fruscio, R., Velsher, L., Zakalik, D., Olopade, O. I., Eng, C., Pal, T., Cullinane, C. A., Couch, F. J., Kotsopoulos, J., & 3 othersSun, P., Lubinski, J. & Narod, S. A., Dec 26 2022, In: Cancer. 129, 6, p. 901-907 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Neoplasms 100%
  • Salpingo-oophorectomy 44%
  • Mastectomy 38%
  • Breast 26%