Keyphrases
Mitophagy
90%
Parkin
83%
Parkinson's Disease
75%
Ubiquitin
70%
Mitochondrial Damage
46%
PTEN-induced Kinase 1 (PINK1)
34%
Mitochondria
32%
Mitochondrium
32%
E3 Ubiquitin Ligase
30%
TAR DNA-binding Protein 43 (TDP-43)
27%
Early Parkinson's Disease
27%
Lewy Body Disease
23%
PINK1-Parkin Pathway
22%
PINK1-PRKN
22%
Alzheimer's Disease
21%
Mitochondrial Quality Control
19%
Alpha-synuclein (α-syn)
17%
Phosphorylated Ubiquitin
17%
Leucine-rich Repeat Kinase 2 (LRRK2)
16%
Parkin-mediated Mitophagy
16%
Kinase Activity
14%
Phosphorylation
14%
Autophagy
13%
Knockdown
12%
Phospho-ubiquitin
12%
Functional Analysis
12%
Neurodegenerative Diseases
12%
Disease-causing mutations
12%
Neuropathology
11%
Mitochondrial Dysfunction
11%
Structural Characterization
11%
Histone Deacetylase 6 (HDAC6)
10%
Isogenic
10%
SQSTM1
10%
DJ-1
10%
UFMylation
10%
Ubiquitin Phosphorylation
10%
PARK2
10%
Protein Level
10%
Damaged Organelles
10%
Lysosome
9%
Disease Pathogenesis
9%
Mitochondrial Stress
9%
Mitochondrial Autophagy
8%
Autopsy Brain
8%
Therapeutic Target
8%
Physiological Relevance
8%
Functional Impact
8%
Ubiquitination
8%
Postmortem Brain
7%
Biochemistry, Genetics and Molecular Biology
PINK1
100%
Mitophagy
83%
Ubiquitin
79%
Kinase
58%
Phosphotransferase
58%
Mitochondrion
52%
Ubiquitin-Conjugating Enzyme
35%
Autophagy
26%
Transactive Response Dna Binding Protein-43
23%
Quality Control
20%
Enzyme Activity
16%
Ubiquitination
16%
TAR DNA Binding Protein
16%
Dopaminergic
16%
Mitochondrial Disorder
14%
Fibroblast
12%
Enzyme
11%
Alpha-Synuclein
10%
Histone Deacetylase
10%
Tau
10%
Conformation
10%
Genetics
9%
LRRK2
9%
Wild Type
9%
Enzymatic Activity
8%
Small Molecule
8%
Exon
7%
Lysosome
6%
Synuclein
6%
Neurofibrillary Tangle
6%
Mitochondrial Targeting Signal
6%
Serine
6%
Allele
6%
Amyloid Protein
6%
Binding Affinity
6%
Electrochemiluminescence
6%
DNA-binding Protein
6%
Loss of Function Mutation
6%
Proband
6%
RNA Binding
6%
Coenzyme
5%
Serine Protease
5%
Bioenergetics
5%
Caenorhabditis Elegans
5%
Voltage-Dependent Anion Channel
5%
Sirtuin
5%
Innate Immunity
5%
PMM2
5%
Cathepsin B
5%
Mitochondrial Fusion
5%
Neuroscience
Mitophagy
71%
Parkinson's Disease
59%
Ubiquitin
46%
Kinase
38%
Mitochondrion
35%
Parkin
33%
Alzheimer's Disease
20%
Dementia with Lewy Bodies
18%
Amyotrophic Lateral Sclerosis
17%
In Vivo
15%
Neurodegenerative Disorder
15%
TAR DNA Binding Protein
12%
Frontotemporal Dementia
12%
Synuclein
10%
Alpha-Synuclein
10%
Histone Deacetylase 6
10%
Ubiquitin Protein Ligase E3
10%
MicroRNA
7%
Parkinsonism
6%
Neurodegeneration
6%
Lewy Body
6%
Fibroblast
6%
Mitochondrial Targeting Signal
6%
Binding Affinity
6%
RNA Binding
6%
Cell Function
6%
DNA-binding Protein
6%
Dynamin
5%
ELISA
5%
Lysosome
5%
Dopaminergic
5%
Voltage Dependent Anion Channel 1
5%
Sirtuin 3
5%
Hexokinase
5%
NBR1
5%
Neurite Outgrowth
5%
Exon Junction Complex
5%
Inflammasome
5%
Myositis
5%
Phosphoserine
5%
S6 Kinase
5%
Caenorhabditis Elegans
5%
Exon
5%
